Preparation and characterization of superparamagnetic streptomycin sulfate PLA-PEG microspheres

WU Can; et al

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Preparation and characterization of superparamagnetic streptomycin sulfate PLA-PEG microspheres

更新时间：2024-01-17

- Preparation and characterization of superparamagnetic streptomycin sulfate PLA-PEG microspheres
- Journal of Chongqing Medical University Vol. 34, Issue 10, Pages: 1321-1325(2009)
- 作者机构：
  
  重庆医科大学附属儿童医院骨科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R944.9
- Published：2009，
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[1]吴灿,刘传康,罗聪,李明.超顺磁性硫酸链霉素PLA-PEG微球的制备和体外特征研究[J].重庆医科大学学报,2009,34(10):1321-1325.

WU Can, et al. Preparation and characterization of superparamagnetic streptomycin sulfate PLA-PEG microspheres. [J]. Journal of Chongqing Medical University 34(10):1321-1325(2009)
[1]吴灿,刘传康,罗聪,李明.超顺磁性硫酸链霉素PLA-PEG微球的制备和体外特征研究[J].重庆医科大学学报,2009,34(10):1321-1325. DOI：

WU Can, et al. Preparation and characterization of superparamagnetic streptomycin sulfate PLA-PEG microspheres. [J]. Journal of Chongqing Medical University 34(10):1321-1325(2009) DOI：

摘要

目的:制备超顺磁性硫酸链霉素（Streptomycinsulfate

SM）PLA-PEG微球（Superparamagnetic streptomycin sulfate PLA-PEG microspheres

spSPM）

探索并建立一种准确、方便和有效的硫酸链霉素HPLC检测方法;研究此微球的特征

并对其在振荡磁场作用下的体外药物释放规律进行研究

为今后的动物实验及临床应用提供理论依据。方法:用化学共沉淀法合成超顺磁性壳聚糖Fe3O4纳米粒（Superparamagnetic chitosan Fe3O4 nanospheres

spCFN）

再用双乳化（W/O/W）溶剂挥发法制备spSPM

检测其特征参数。将此spSPM在37℃模拟体液中进行体外药物溶出试验

振荡磁场干预

用HPLC检测硫酸链霉素（SM）的释放量。结果:本实验制备的spSPM包封率47.56%±1.39%

载药量25.20%±1.52%

体积平均粒径为2.467μm

体外释放周期超过7 d。结论:本实验制备的spSPM具有隐形微球的各项特征

可应用于进一步的研究中。

Abstract

Objective:Preparation of superparamagnetic sulfate streptomycin PLA-PEG microspheres(spSPM)

and try to establish of an accurate

convenient and effective detection method of high performance liquid chromatography(HPLC) about streptomycin sulfate(SM);to research the properties of this microspheres

and study the laws of drug release under oscillating magnetic field interfered in vitro.This will provide a theoretical basis for our animal experiments and clinical application in the future.Methods:Using chemical coprecipitation to synthesize superparamagnetic chitosan Fe3O4 nanospheres(spCFN)

and then using complex emulsification(W/O/W) to prepare spSPM;put spSPM in simulated body fluid at 37℃

oscillating magnetic field interferes and use HPLC to detect the release of SM.Results:The entrapment rate of this spSPM is 47.56%±1.39%

s drug-loading rate is 25.20%±1.52%

the volume averaging particle size is 2.467μm

the cycle of this drug delivery system is more than seven days.Conclusion:The spSPM prepared by this method has all characteristics of the stealh microspheres

and oscillating magnetic field can increase the dissolution of this system repeatability

thus it can be used in further studies.

关键词

硫酸链霉素高效液相色谱超顺磁性微球聚乳酸-聚乙二醇振荡磁场控释

Keywords

Streptomycin sulfateHPLCSuperparamagnetic microspheresPolylactide-Polyethylene glycolOscillating magnetic fieldsControlled release

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