Effect of irbesartan on the expression of PPAR-γ and ventricular remodeling in rats with myocardial infarction

LIU Jun; et al

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Effect of irbesartan on the expression of PPAR-γ and ventricular remodeling in rats with myocardial infarction

更新时间：2024-01-17

- Effect of irbesartan on the expression of PPAR-γ and ventricular remodeling in rats with myocardial infarction
- Journal of Chongqing Medical University Vol. 34, Issue 12, Pages: 1670-1672(2009)
- 作者机构：
  
  重庆医科大学附属第一医院心内科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R542.22
- Published：2009，
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[1]刘俊,覃数,杨义,何泉.厄贝沙坦对大鼠梗死心肌PPAR-γ表达及心室重塑的影响[J].重庆医科大学学报,2009,34(12):1670-1672.

LIU Jun, et al. Effect of irbesartan on the expression of PPAR-γ and ventricular remodeling in rats with myocardial infarction. [J]. Journal of Chongqing Medical University 34(12):1670-1672(2009)
[1]刘俊,覃数,杨义,何泉.厄贝沙坦对大鼠梗死心肌PPAR-γ表达及心室重塑的影响[J].重庆医科大学学报,2009,34(12):1670-1672. DOI：

LIU Jun, et al. Effect of irbesartan on the expression of PPAR-γ and ventricular remodeling in rats with myocardial infarction. [J]. Journal of Chongqing Medical University 34(12):1670-1672(2009) DOI：

摘要

目的:检测过氧化物酶体增殖物激活受体（Peroxisome proliferator-activated receptorγ

PPAR-γ）在大鼠心肌梗死时心肌细胞中的表达水平

探讨厄贝沙坦逆转心室重塑的机制是否与PPAR-γ有关。方法:结扎大鼠冠状动脉前降支建立心肌梗死模型

24h后存活大鼠随机分成心肌梗死（Myocardial infarction

MI）组、厄贝沙坦（Irbesartan

Ire）组75mg（/kg·d）

另设假手术（Sham）组。6周后测定PPAR-γmRNA及蛋白的表达情况

左室重量指数

心肌细胞横切面积

测定心肌胶原容积分数。结果:与假手术组比较

MI组大鼠心肌中PPAR-γmRNA及蛋白表达水平显著降低

左室重量指数增加

心肌细胞横截面积增加

非梗死区胶原沉积明显

胶原比例增加。Ire组心肌中PPAR-γmRNA及蛋白表达水平增高

左室重量指数降低

心肌细胞横截面积减少

非梗死区胶原沉积减少。结论:PPAR-γ在大鼠心肌梗死时心肌细胞中的表达下调;厄贝沙坦可能通过上调并激活PPAR-γ逆转心肌梗死后左室重塑。

Abstract

Objective:To study the expreesion of PPAR-γ in the left ventricular myocardium in rats with myocardial infarction

and to investiagate whether the mechanism of Irbesartan reversing the ventricular remodeling is related to PPAR-γ.Methods:Myocardial infarction models were successfully induced by ligation of anterior descending coronary artery.24 h later the survivors were randomly divided into 3 groups.① MI group;② Irbesartan group 75 mg/(kg·d);③ The rats with sham ligation formed Sham group.After 6 weeks

the expreesion of PPAR-γ

the ratio of LV weight to body weight(LVWI)

cross-section area(CSA)of left ventricular myocardium were examined.The collagen volume fraction(CVF) were analyzed by PSR dyeing.Results:In MI group

compared with those in Sham group

the expreesion of PPAR-γmRNA and protein in the left ventricular myocardium decraced significantly

but the LVWI

CSA and the CVF in non-infarcted zone increased.Compared with those in MI group

in Ire group

the expreesion of PPAR-γmRNA and protein in cadiocyte incraced

while the LVWI 、CSA and the CVF in non-infarcted zone decreased.Conculusion:The expression of PPAR-γ is down-regulated in the left ventricular myocardium with myocardial infarction

Irbesartan reverses the left ventricular remodeling possibly by up-regulating and activating PPAR-γ.

关键词

过氧化物酶体增殖物激活受体心肌梗死厄贝沙坦心室重塑

Keywords

PPAR-γmyocardial infarctionirbesartanVentricular remodeling

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