The effect of heme oxygenase-1 on erythropoietin protection ischemia reperfusion injury in the mouse kidney

YI Shan-hong; et al

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The effect of heme oxygenase-1 on erythropoietin protection ischemia reperfusion injury in the mouse kidney

更新时间：2024-01-17

- The effect of heme oxygenase-1 on erythropoietin protection ischemia reperfusion injury in the mouse kidney
- Journal of Chongqing Medical University Vol. 34, Issue 9, Pages: 1151-1153(2009)
- 作者机构：
  
  第三军医大学附属新桥医院泌尿外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R363
- Published：2009，
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[1]易善红,叶钢.HO-1在EPO保护小鼠肾缺血再灌注损伤中的作用[J].重庆医科大学学报,2009,34(09):1151-1153.

YI Shan-hong, et al. The effect of heme oxygenase-1 on erythropoietin protection ischemia reperfusion injury in the mouse kidney. [J]. Journal of Chongqing Medical University 34(9):1151-1153(2009)
[1]易善红,叶钢.HO-1在EPO保护小鼠肾缺血再灌注损伤中的作用[J].重庆医科大学学报,2009,34(09):1151-1153. DOI：

YI Shan-hong, et al. The effect of heme oxygenase-1 on erythropoietin protection ischemia reperfusion injury in the mouse kidney. [J]. Journal of Chongqing Medical University 34(9):1151-1153(2009) DOI：

摘要

目的:探讨血红素氧化酶-1（Heme oxygenase-1

HO-1）对促红细胞生成素（Erythropoietin

EPO）减轻小鼠肾缺血再灌注损伤的保护机制中的作用。方法:建立小鼠肾缺血再灌注损伤模型

80只雄性小鼠分为锌原卟啉（ZnPP）组、EPO治疗组、缺血组及对照组4组

检测血丙二醛（MDA）、肌酐（Cr）、尿素氮（BUN）和肾组织匀浆超氧化物歧化酶（Superoxide dismutase

SOD）、白介素-6（IL-6）水平以及HO-1的变化。结果:EPO组的HO-1酶活性明显升高、HO-1蛋白表达增加

同时血浆MDA、Cr、BUN水平较缺血组显著下降（P<0.05）

肾组织匀浆SOD显著升高、IL-6显著降低（P<0.05）;ZnPP组的肾保护作用较EPO组显著降低。结论:EPO对肾缺血再灌注损伤的保护作用可能与HO-1活性增强有关。

Abstract

Objective:To study the effect of heme oxygenase-1 on erythropoietin protection renal ischemia reperfusion injury in mice. Methods:male mice were used to make ischemic model by clamping left renal artery for 45min

80 male mice were separated with four groups. Group 1 (n=20) as control group

group 2 (n=20) as ischemia group

group 3 (n=20) received EPO treatment. group 4 (n=20) received EPO and ZnPP treatment. Plasma MDA

BUN and tissue SOD

IL-6 were observed. the enzyme activity and expression of heme oxygenase-1 were detected. Results:The enzyme activity and expression of heme oxygenase-1 of EPO groups were enhanced

and plasma MDA

BUN and tissue IL-6 of EPO groups were significantly lower than those ischemia groups. SOD was significantly higher. The protection effects of EPO on renal IRI were reduced of ZNPP group. Conclusion:The protective effect of erythropoietin on renal ischemia reperfusion injury in mice related on increasing heme oxygenase-1enzyme activity.

关键词

肾缺血再灌注损伤促红细胞生成素、HO-1

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