Study of pioglitazone treatment for experimental atherosclerosis mice

WU Cheng-wen; ZHOU Zhi-qiang

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Study of pioglitazone treatment for experimental atherosclerosis mice

更新时间：2024-01-17

- Study of pioglitazone treatment for experimental atherosclerosis mice
- Journal of Chongqing Medical University Vol. 36, Issue 11, Pages: 1329-1331(2011)
- 作者机构：
  
  郑州大学第二附属医院普外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R965
- Published：2011，
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[1]吴成稳,周志强.吡格列酮对实验性动脉粥样硬化小鼠治疗作用研究[J].重庆医科大学学报,2011,36(11):1329-1331.

WU Cheng-wen, ZHOU Zhi-qiang. Study of pioglitazone treatment for experimental atherosclerosis mice. [J]. Journal of Chongqing Medical University 36(11):1329-1331(2011)
[1]吴成稳,周志强.吡格列酮对实验性动脉粥样硬化小鼠治疗作用研究[J].重庆医科大学学报,2011,36(11):1329-1331. DOI：

WU Cheng-wen, ZHOU Zhi-qiang. Study of pioglitazone treatment for experimental atherosclerosis mice. [J]. Journal of Chongqing Medical University 36(11):1329-1331(2011) DOI：

摘要

目的:研究吡格列酮对小鼠动脉粥样硬化（Atherosclerosis

AS）斑块面积以及对基质金属蛋白酶9（Matrix metallopro-teinases-9

MMP-9）表达的影响。方法:小鼠高脂饮食造模16周复制小鼠AS模型

从第8周开始给予吡格列酮

观察吡格列酮对血脂含量以及AS斑块面积的影响

免疫组织化学方法检测MMP-9表达。结果:与模型组相比

吡格列酮10 mg/kg可以显著降低AS小鼠甘油三酯、总胆固醇、低密度脂蛋白的水平（P<0.05）

对高密度脂蛋白含量影响不大（P>0.05）

吡格列酮可以减少主动脉斑块面积（P<0.05）

降低MMP-9的表达（P<0.05）。结论:吡格列酮可能通过降低AS小鼠MMP-9的表达抑制AS。

Abstract

Objective:To study the inhibition effect of pioglitazone on the aortic plaque area of murine atherosclerosis and the expression of MMP-9.Methods:Mice were fed with high fat diets to build the model of atherosclerosis for 16 weeks.Pioglitazone was given from the 8th week and that effect on blood lipids

atherosclerotic plaque area and the expression of MMP-9 was observed through immunohistochemistry.Results:The concentrations of TC

TG and LDL were significantly reduced by pioglitazone at a dose of 10 mg/kg

but pioglitazone had little effect on HDL.Meanwhile

pioglitazone could reduce the aortic plaque area and the MMP-9 expression.Conclusion:Pioglitazone might inhibit atherosclerosis in mice by decreasing the expression of MMP-9.

关键词

吡格列酮动脉粥样硬化基质金属蛋白酶9

Keywords

pioglitazoneatherosclerosismatrix metalloproteinases-9(MMP-9)

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