Meta-analysis of cardiac resynchronization therapy for heart failure patients

LU Ting-yi; KAO Guo-ying; SU Li

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Meta-analysis of cardiac resynchronization therapy for heart failure patients

更新时间：2024-01-17

- Meta-analysis of cardiac resynchronization therapy for heart failure patients
- Journal of Chongqing Medical University Vol. 36, Issue 10, Pages: 1237-1242(2011)
- 作者机构：
  
  重庆医科大学附属第二医院心内科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R541.61
- Published：2011，
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[1]卢庭义,考国营,苏立.心脏再同步化治疗心力衰竭的Meta分析[J].重庆医科大学学报,2011,36(10):1237-1242.

LU Ting-yi, KAO Guo-ying, SU Li. Meta-analysis of cardiac resynchronization therapy for heart failure patients. [J]. Journal of Chongqing Medical University 36(10):1237-1242(2011)
[1]卢庭义,考国营,苏立.心脏再同步化治疗心力衰竭的Meta分析[J].重庆医科大学学报,2011,36(10):1237-1242. DOI：

LU Ting-yi, KAO Guo-ying, SU Li. Meta-analysis of cardiac resynchronization therapy for heart failure patients. [J]. Journal of Chongqing Medical University 36(10):1237-1242(2011) DOI：

摘要

目的:评价心脏再同步化治疗（伴或不伴除颤功能）在降低心力衰竭患者的死亡率方面的作用。方法:查阅已公开发表的有关心脏再同步化治疗心力衰竭的临床随机对照试验文献

以死亡率为主要评价指标

用Cochrane协作网的软件RevMan5.1进行Meta分析。结果:本次分析最终纳入文献12篇（n=7 539）。与单纯药物治疗组相比

心脏再同步化治疗（Cardiac resyn-chronization therapy

CRT）加药物治疗组的死亡率明显降低（RR 0.73

95%CI 0.62-0.85）;而与埋藏式除颤器（Implantable car-dioverter defibrillator

ICD）治疗组相比

带除颤功能的心脏再同步化治疗组（CRT-D）死亡率亦显著降低（RR 0.83

95%CI 0.72-0.96）。在心功能Ⅰ、Ⅱ级（NYHA）的心力衰竭患者中

上述结果十分明显（RR 0.81

95%CI 0.67-0.97）;但在心功能Ⅲ、Ⅳ级的患者中则不然（RR 0.86

95%CI 0.69-1.07）。结论:药物加心脏再同步化治疗及具备除颤功能的心脏再同步化治疗能显著降低心力衰竭患者的死亡率。

Abstract

Objective:To evaluate the effect of cardiac resynchronization therapy

with or without implantable defibrillator

on mortality in patients with heart failure.Methods:The published literatures related to clinical randomized controlled trials on cardiac resynchronization therapy were searched

mainly with mortality as result indicators

and software RevMan5.1 in Cochrane Cooperation Net was used to process meta-analysis.Results:12 studies(n=7 539) were included in this meta-analysis.Compared with simple drug therapy

cardiac resynchronization therapy plus medical therapy significantly reduced mortality(relative risk 0.73

95% confidence interval 95%CI 0.62-0.85).Compared with an implantable defibrillator

cardiac resynchronization therapy plus an implantable defibrillator significantly reduced mortality(RR 0.83

95%CI 0.72-0.96).This finding remained significant in patients with New York Heart Association(NYHA) class Ⅰ or Ⅱ(RR 0.81

95%CI 0.67-0.97)

but not in those with class Ⅲ or Ⅳ(RR 0.86

95%CI 0.69-1.07).Conclusion:Compared with optimal drug therapy

the cardiac resynchronization therapy

with or without implantable defibrillator

significantly reduces mortality in patients with heart failure.

关键词

心脏再同步化治疗心力衰竭Meta分析

Keywords

cardiac resynchronization therapyheart failureMeta-analysis

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