Objective:To investigate the accuracy of Thin-Prep-liquid-based cytology test for cervical lesion with histopathological diagnosis as the criteria.Methods:TCT results of 38088 cases admitted to the First Affiliated Hospital of Chongqing Medical University from July 2003 to July 2007 were retrospectively studied.The patients with positive result underwent regular check or colposcopy

and

if necessary

cervical biopsy under guidance of colposcope.A total of 1 556 samples with complete data were divided into groups and analyzed.The relativity of TCT results to biopsy pathological diagnosis was statistically analyzed.Results:The results of TCT examination for 38 088 cases indicated that 2 462 cases were abnormal and 1 556 cases had definite colposcope directed biopsy results

and the pathological results confirmed that the abnormal cases of CINⅠ

CINⅡ

CINⅢ

ICC and HPV infection were 279

314

365

75 and 94 respectively.The agreement of TCT and pathological results was 60.35%.The sensitivity and specificity of TCT were 0.84 and 0.53 respectively.The positive and negative predictive values were 0.83 and 0.56 respectively.CIN and HPV had high incidences at age 30 to 39

while ICC peaked at 30 to 49.In TCT positive group

the relative risks of ASC progressing to CINⅠ

CINⅡ and CINⅢ were 11.11

13.21 and 8.19 respectively of LSIL progressing to CINⅠ

CINⅡ and CINⅢ were 22.60

20.72 and 13.66 respectively and of HSIL progressing to CINⅠ

CINⅡ and CIN3 were 10.33

25.45 and 54.65 respectively.Conclusion:TCT has high agreement with biopsy in positive rate and positive predictive rate for cervical lesion screening

which suggests that TCT has certain predicative value for pathological results.The risk of cervical lesion in TCT positive group is significantly higher than that in negative group.