FOXC1 expression in relapsing invasive ductal carcinoma

JIA Hai-quan; ZHAO Guo-qiang

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FOXC1 expression in relapsing invasive ductal carcinoma

更新时间：2024-01-17

- FOXC1 expression in relapsing invasive ductal carcinoma
- Journal of Chongqing Medical University Vol. 36, Issue 11, Pages: 1372-1374(2011)
- 作者机构：
  
  郑州大学基础医学院病理学与病理生理学教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.9
- Published：2011，
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[1]贾海全,赵国强.FOXC1在复发性乳腺浸润性导管癌中的表达及其意义[J].重庆医科大学学报,2011,36(11):1372-1374.

JIA Hai-quan, ZHAO Guo-qiang. FOXC1 expression in relapsing invasive ductal carcinoma. [J]. Journal of Chongqing Medical University 36(11):1372-1374(2011)
[1]贾海全,赵国强.FOXC1在复发性乳腺浸润性导管癌中的表达及其意义[J].重庆医科大学学报,2011,36(11):1372-1374. DOI：

JIA Hai-quan, ZHAO Guo-qiang. FOXC1 expression in relapsing invasive ductal carcinoma. [J]. Journal of Chongqing Medical University 36(11):1372-1374(2011) DOI：

摘要

目的:探讨FOXC1蛋白表达与复发性乳腺浸润性导管癌的临床病理特征间相关性。方法:采用免疫组化S-P法检测42例复发性乳腺癌石蜡组织中FOXC1蛋白的表达。结果:FOXC1蛋白在21例（50%）乳腺浸润性导管癌中表达

定位于胞核。FOXC1阳性表达与乳腺浸润性导管癌组织学分级相关（P<0.05）

与复发性乳腺癌患者的耐药情况及患者辅助化疗后的PFS相关（P<0.05）

与乳腺癌患者的年龄

淋巴结转移的数量以及原发肿块的大小无明显的统计学相关性（P>0.05）。结论:FOXC1蛋白参与了复发性乳腺癌的耐药机制

但其可能与乳腺癌原发肿瘤的发生发展及淋巴结转移无关。

Abstract

Objective:To investigate potential correlations between FOXC1 expression and clinicopathologic features of relapsing invasive ductal carcinoma.Methods:FOXC1 protein expression in 42 cases of relapsing invasive ductal carcinoma were investigated with immunohistochemistry.Results:FOXC1 protein expression was observed in invasive ductal carcinoma tissues.Positive FOXC1 expression was revealed in 21(50.0 %)invasive ductal carcinoma.Significant correlation in retrospective study was observed between FOXC1 protein expression and histological grades(P<0.05)as well as drug resistance and PFS after adjuvant chemotherapy(P<0.05).No significant association was shown between FOXC1 protein expression in invasive ductal carcinoma and clinicopathological factors including pathological type

age

primary tumor size

TNBC and non-TNBC

lymph node metastasis

etc(P>0.05).Conclusion:FOXC1 may play a role in malignant degree and drug resistance to relapsing invasive ductal carcinoma.

关键词

复发性乳腺癌转录因子FOXC1免疫组化

Keywords

relapsing invasive ductal carcinomatranscriptional factor FOXC1immunohistochemistry

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