False discovery rate and its extension and application

WANG Ting; ZENG Ping; HUANG Shui-ping; ZHAO Hua-shuo

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False discovery rate and its extension and application

更新时间：2024-01-17

- False discovery rate and its extension and application
- Journal of Chongqing Medical University Vol. 36, Issue 12, Pages: 1445-1448(2011)
- 作者机构：
  
  徐州医学院公共卫生学院流行病与卫生统计学教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R181.3
- Published：2011，
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[1]王婷,曾平,黄水平,赵华硕.错误发现率及其扩展和应用[J].重庆医科大学学报,2011,36(12):1445-1448.

WANG Ting, ZENG Ping, HUANG Shui-ping, et al. False discovery rate and its extension and application. [J]. Journal of Chongqing Medical University 36(12):1445-1448(2011)
[1]王婷,曾平,黄水平,赵华硕.错误发现率及其扩展和应用[J].重庆医科大学学报,2011,36(12):1445-1448. DOI：

WANG Ting, ZENG Ping, HUANG Shui-ping, et al. False discovery rate and its extension and application. [J]. Journal of Chongqing Medical University 36(12):1445-1448(2011) DOI：

摘要

目的:介绍多重假设检验中的错误发现率控制和在此基础上发展起来的q值和局部错误发现率。方法:将Benjamini和Hochberg（BH）控制程序、q值和局部错误发现率应用于一个前列腺癌微阵列数据的基因差别表达分析

控制和估计错误发现率。结果:当错误发现率为0.10时通过BH程序得到60个差别表达基因

q值小于0.10的有74个基因

局部错误发现率小于0.10的有31个基因。结论:高维数据多重假设检验中能同时控制或估计错误发现率

BH控制程序、q值和局部错误发现率的联合应用能提供更多的信息。

Abstract

Objective:To introduce the multiple hypothesis testing based on the false discovery rate and its extension to q value and local false discovery rate.Methods:False discovery rate

q value and local false discovery rate were applied to the analysis of differentially expressed genes concerning a prostate cancer microarray data to control and estimate the false discovery rate.Results:It identified 60 differentially expressed genes with the procedure of Benjamini and Hochberg when controlling the false discovery rate below 0.10

74 genes with q value less than 0.10 and 31 genes with local false discovery rate less than 0.10.Conclusion:We can control and estimate false discovery rate simultaneously in multiple comparisons of high-dimensional data.It can provide more information for analysis to combine false discovery rate

q value and local false discovery rate.

关键词

微阵列数据多重假设检验错误发现率q值局部错误发现率前列腺癌

Keywords

microarray datamultiple hypothesis testingfalse discovery rateq valuelocal false discovery rateprostate cancer

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Related Institution

Molecular Medicine and Tumor Research Center of Chongqing Medical University

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