An investigation of PD-L1,PD-L2 and B7-H4 expressions in human cervical cancer and their significance

GENG Wei-pu; XU Man; WANG Yu-qi; XU Guang-xu; CHEN Yu; WANG Ting-ting; HUANG Wen-lian; ZHAO Yong

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An investigation of PD-L1,PD-L2 and B7-H4 expressions in human cervical cancer and their significance

更新时间：2024-01-17

- An investigation of PD-L1,PD-L2 and B7-H4 expressions in human cervical cancer and their significance
- Journal of Chongqing Medical University Vol. 36, Issue 10, Pages: 1186-1189(2011)
- 作者机构：
  
  1. 重庆医科大学基础医学院病理教研室
  2. 重庆医科大学分子与肿瘤研究中心
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.33
- Published：2011，
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[1]耿卫朴,徐曼,王渝琦,徐光旭,陈瑜,王婷婷,黄文炼,赵涌.共刺激分子PD-L1、PD-L2和B7-H4在人子宫颈癌的表达及意义[J].重庆医科大学学报,2011,36(10):1186-1189.

GENG Wei-pu, XU Man, WANG Yu-qi, et al. An investigation of PD-L1,PD-L2 and B7-H4 expressions in human cervical cancer and their significance. [J]. Journal of Chongqing Medical University 36(10):1186-1189(2011)
[1]耿卫朴,徐曼,王渝琦,徐光旭,陈瑜,王婷婷,黄文炼,赵涌.共刺激分子PD-L1、PD-L2和B7-H4在人子宫颈癌的表达及意义[J].重庆医科大学学报,2011,36(10):1186-1189. DOI：

GENG Wei-pu, XU Man, WANG Yu-qi, et al. An investigation of PD-L1,PD-L2 and B7-H4 expressions in human cervical cancer and their significance. [J]. Journal of Chongqing Medical University 36(10):1186-1189(2011) DOI：

摘要

目的:研究共刺激分子程序性死亡配体1（Programmed death ligand 1

PD-L1）、程序性死亡配体2（Programmeddeath ligand 2

PD-L2）和B7-H4在人子宫颈癌的表达及其与临床病理特征的关系。方法:采用免疫组织化学PV-6000法检测PD-L1、PD-L2和B7-H4在10例正常人宫颈组织、10例高级别CIN（CINⅡ

Ⅲ

级）和67例子宫颈癌中的表达

并分析3种共刺激分子的表达与子宫颈患者临床病理特征的相关性。结果:正常人宫颈组织上皮不表达PD-L1和B7-H4

而基底层细胞微弱表达PD-L2;CINⅡ

Ⅲ

的瘤变宫颈上皮微弱表达PD-L1、PD-L2和B7-H4;子宫颈癌细胞表达PD-L1、PD-L2和B7-H4的阳性率分别为70%（47/67）、51%（34/67）和46%（31/67）。统计学分析显示宫颈癌细胞PD-L1的表达与癌细胞浸润深度明显相关（P

0.01）

与年龄、组织学类型无关;PD-L2的表达与肿瘤的淋巴结转移（P

0.05）有关;B7-H4的表达与肿瘤的淋巴结转移（P

0.05）和局部血管内瘤栓形成（P

0.05）相关。结论:人子宫颈癌细胞异常表达PD-L1、PD-L2和B7-H4

且与肿瘤浸润和转移密切相关。PD-L1、PD-L2和B7-H4可能成为子宫颈癌免疫治疗的潜在靶点。

Abstract

Objective:To investigate the expressions of co-stimulation molecules PD-L1

PD-L2 and B7-H4 in human cervical cancers and their association with clinical and pathologic characteristics of the patients.Methods:The expressions of PD-L1

PD-L2 and B7-H4 in 10 cases of normal human cervical tissue

10 cases of CINⅡ~Ⅲ

and 67 cases of cervical cancer were detected by immunohistochemistry PV-6000 staining

and the relationship of their expressions to clinical and pathologic characteristics was evaluated.Results:There was no PD-L1 or B7-H4 expression in normal cervical tissue

but weak expression of PD-L2 in basal cervical epithelium;faint expressions of PD-L1

PD-L2 and B7-H4 were determined in CINⅡ~Ⅲ;70%(47/67)PD-L1

51%(34/67)PD-L2 and 46%(31/67)B7-H4 were detected in cervical cancers.PD-L1 expression in cancer cells was related to the cancer invasion depth(P<0.01)

PD-L2 expression related to the lymph node metastasis(P<0.05)

and B7-H4 expression related to lymph node metastasis(P<0.05)and vascular invasion(P<0.05).Conclusion:PD-L1

PD-L2 and B7-H4 express aberrantly in cervical cancer and are closely associated with the invasion and metastasis of cervical cancer.PD-L1

PD-L2 and B7-H4 may be the potential immunotherapy targets of cervical cancer.

关键词

PD-L1、PD-L2、B7-H4子宫颈癌免疫组织化学

Keywords

PD-L1PD-L2B7-H4cervical cancerimmunohistochemistry

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