Expressions of vascular endothelial growth factor and its soluble receptor 1 in ovarian tissues and serum of polycystic ovary syndrome

ZHANG Jia-jia; ZHAO Chun-quan

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Expressions of vascular endothelial growth factor and its soluble receptor 1 in ovarian tissues and serum of polycystic ovary syndrome

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- Expressions of vascular endothelial growth factor and its soluble receptor 1 in ovarian tissues and serum of polycystic ovary syndrome
- Journal of Chongqing Medical University Vol. 36, Issue 10, Pages: 1180-1183(2011)
- 作者机构：
  
  重庆医科大学附属第一医院妇产科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R711.75
- Published：2011，
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[1]张家佳,赵纯全.血管内皮生长因子及其可溶性受体1在多囊卵巢综合征患者血清和卵巢组织的表达[J].重庆医科大学学报,2011,36(10):1180-1183.

ZHANG Jia-jia, ZHAO Chun-quan. Expressions of vascular endothelial growth factor and its soluble receptor 1 in ovarian tissues and serum of polycystic ovary syndrome. [J]. Journal of Chongqing Medical University 36(10):1180-1183(2011)
[1]张家佳,赵纯全.血管内皮生长因子及其可溶性受体1在多囊卵巢综合征患者血清和卵巢组织的表达[J].重庆医科大学学报,2011,36(10):1180-1183. DOI：

ZHANG Jia-jia, ZHAO Chun-quan. Expressions of vascular endothelial growth factor and its soluble receptor 1 in ovarian tissues and serum of polycystic ovary syndrome. [J]. Journal of Chongqing Medical University 36(10):1180-1183(2011) DOI：

摘要

目的:研究多囊卵巢综合征（Polycystic ovary syndrome

PCOS）患者与正常对照组血液和卵巢组织中血管内皮细胞生长因子（Vascular endothelial growth factor

VEGF）及其可溶性受体1（Soluble vascular endothelial growth factor receptor 1

sFlt-1）表达水平

探讨其对PCOS发生和发展的影响。方法:应用酶联免疫吸附（Enzyme-linked immunosorbent assay

ELISA）法测定46例PCOS患者及25例对照者血清中VEGF、sFlt-1浓度。应用免疫组化SP法检测9例PCOS患者及7例对照患者卵巢组织VEGF、sFlt-1的表达。结果:（1）在血清中

PCOS组的VEGF、sFlt-1浓度中位数分别49.18 pg/ml、49.25 ng/L

对照组分别为34.45 pg/ml、389.37 ng/L

两组比较差异有统计学意义（P<0.05）。（2）在卵巢组织中

PCOS组的VEGF、sFlt-1灰度值表达分别为0.24±0.03、0.17±0.04

对照组为0.18±0.02、0.26±0.05

两组比较差异有统计学意义（P<0.05）。（3）在血清和卵巢组织中

VEGF生物利用度（VEGF/sFlt-1）均高于对照组

差异有统计学意义。（4）在血清中研究VEGF与sFlt-1相关性

两者为负性相关关系（rs=-0.435

P<0.05）。结论:血清和卵巢组织中sFlt-1表达下降

可能引起了VEGF表达的增加

共同参与PCOS卵巢血管的形成

从而促进PCOS的发生和发展。

Abstract

Objective:To investigate the expressions of vascular endothelial growth factor(VEGF) and its soluble receptor 1(sFlt-1) in ovarian tissues and serum of polycystic ovary syndrome(PCOS) and control group.Methods:Enzyme linked immunosorbent assay(ELISA) was used to investigate the expressions of VEGF and sFlt-1 in the serum of 46 PCOS patients(experimental group) and 25 normal control subjects(control group).The levels of VEGF and sFlt-1 in ovarian tissues were detected by Sp immunohistochemical method(including 9 PCOS cases and 7 control cases).Results:1.In serum

VEGF and sFlt-1 concentrations were 49.18 pg/ml and 49.25 ng/L respectively in PCOS group

and were 34.45 pg/ml and 389.37 ng/L respectively in the control group.There were significant differences in the two groups(P<0.05).2.In ovarian tissues

VEGF and sFlt-1 expressions were 0.24±0.03 and 0.17±0.04 respectively in PCOS group

and were 0.18±0.02 and 0.26±0.05 in control group.The differences were statistically significant(P<0.05).3.In serum and ovarian tissues

VEGF bioavailability(VEGF/sFlt-1) was higher than that in control group

and the differences were statistically significant.4.Research in serum VEGF and sFlt-1 correlation found there was negative correlation(rs=-0.435

P<0.05).Conclusion:In serum and ovarian tissues

the decrease of sFlt-1 expression may increase the expression the VEGF

and they both may participate in the formation of ovarian blood vessels of PCOS

thus affecting the occurrence and development of the syndrome.

关键词

多囊卵巢综合征血管内皮生长因子可溶性血管内皮生长因子受体

Keywords

polycystic ovary syndromevascular endothelial growth factorsoluble vascular endothelial growth factor receptor

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