Research advances in the role of DPP4 inhibitor in the pathogenesis of nonalcoholic fatty liver disease

Zhang Xiao; Wang Hui; Wang Yuan; Tong Qiang; Zheng Hongting

您当前的位置：

首页 >

文章列表页 >

Research advances in the role of DPP4 inhibitor in the pathogenesis of nonalcoholic fatty liver disease

更新时间：2023-12-22

- Research advances in the role of DPP4 inhibitor in the pathogenesis of nonalcoholic fatty liver disease
- Journal of Chongqing Medical University Vol. 43, Issue 12, Pages: 1619(2018)
- 作者机构：
  
  陆军军医大学第二附属医院内分泌科
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2018，
扫描看全文
Zhang Xiao, Wang Hui, Wang Yuan, et al. Research advances in the role of DPP4 inhibitor in the pathogenesis of nonalcoholic fatty liver disease. [J]. Journal of Chongqing Medical University 43(12):1619(2018)
DOI：

Zhang Xiao, Wang Hui, Wang Yuan, et al. Research advances in the role of DPP4 inhibitor in the pathogenesis of nonalcoholic fatty liver disease. [J]. Journal of Chongqing Medical University 43(12):1619(2018) DOI：

摘要

非酒精性脂肪肝是指除酒精和药物、遗传疾病等其他明确因素之外所诱导的肝脏病变，它的发病机制可能是胰岛素抵抗、脂代谢紊乱、氧化应激等。DPP-4抑制剂等降糖药物对其具有保护作用，其作用机制可能是改善胰岛素抵抗、抑制脂质合成、抑制炎症反应等。非酒精性脂肪肝发病率逐年上升，但临床上仍缺乏有效的干预措施，根据其发病机制需积极地寻找治疗手段。

Abstract

Nonalcoholic fatter liver disease（NAFLD） refers to liver lesions induced by the factors other than alcohol，drugs，and hereditary diseases，and its pathogenesis may be insulin resistance，dyslipidemia，and oxidative stress. Hypoglycemic agents including DPP4 inhibitor exert a protective effect against NAFLD，possibly by improving insulin resistance and inhibiting lipid synthesis and in－flammatory response. The incidence rate of NAFLD is increasing year by year，but there are still no effective intervention measures in clinical practice. Treatment measures should be actively explored based on pathogenesis.

关键词

非酒精性脂肪肝DPP-4抑制剂降糖药物

Keywords

nonalcoholic fatty liver diseaseDPP4 inhibitorhypoglycemic agent

references

Views

100

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Mediating role of TYG-BMI in vitamin D and nonalcoholic fatty liver disease

Danggui Shaoyao Powder improves inflammatory response in rats with nonalcoholic fatty liver disease induced by high-fat diet by regulating the Sirt1/NF-κB signaling pathway

Effects of p38 mitogen-activated protein kinase in rats with nonalcoholic fatty liver disease

Prevalence of nonalcoholic fatty liver disease in health medical examination participants from Chongqing:a single-center study based on the ZJU index

Changes of plasma Interleukin-6 and TNF-α in the development of nonalcoholic fatty liver rats induced by high fat diet

Related Author

Sun Wenwen

Xing Yuling

Huo Lijing

Kong Dexian

Ma Huijuan

Zhang Zhiyu

Yu Mingxia

Ye Ke

Related Institution

Graduate School，North China University of Science and Technology

Department of Endocrinology， Hebei General Hospital

Laboratory medicine department，Hebei General Hospital

Graduate School， Hebei North University

Graduate School，Hebei Medical University

⁰