High-pressure injection of iodine contrast media（ICM） through vascular access is a necessary step in contrast-enhanced CT，but it is hard for patients with severe and acute diseases or especially-bad vascular conditions to reach peripheral vascular ac－cess. Therefore，central venous catheter can be an alternative. This paper reviewed studies at home and abroad concerning the safety of high-pressure injection of ICM via central venous catheter，providing a reference to infusion channels for patients with particularly difficult puncture and a guidance for further research.