Objective：To review the clinical experience of video-assisted thoracoscopic lobectomy for lung cancer. Methods：From January 2009 to January 2011，52 patients with lung cancer underwent VATS lobectomy.Among them，38 were males and 14 were fe－males，aged 38~72 years old.The average age was 58.Video-assisted thoracoscopic surgical approach included lobectomy and lymph node dissection. Results：Because of 5 cases of pleural adhesion and 2 cases of bleeding，VATS was converted to transit-assisted small incision.All operative time was 90～240 min，with an average of 120 min. Intraoperative bleeding volume was 50～300 ml，with an average of 120 ml.7～19 pieces of lymph nodes were removed，with an average of 14.8. The length of hospital stay was 6～10 days，with an average of 7 days. Postoperative complications：there were no postoperative chylothorax，lung infection，or respiratory insuffi－ciency. Conclusion：VATS lobectomy for lung cancer is a feasible operation with minimal invasion and fewer perioperative compli－cations，whose effect is comparable to thoracotomy lobectomy.