Evaluation on hepatic fibrosis by joint non-invasive method

GU Sai; HUANG Miaoxing

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Evaluation on hepatic fibrosis by joint non-invasive method

更新时间：2023-12-18

- Evaluation on hepatic fibrosis by joint non-invasive method
- Journal of Chongqing Medical University Vol. 36, Issue 1, Pages: 77-80(2013)
- 作者机构：
  
  1. 重庆医科大学附属第一医院消化内科,重庆,400016
  2. 东莞市人民医院临床功能科,广东,523059
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2013，
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GU Sai, HUANG Miaoxing. Evaluation on hepatic fibrosis by joint non-invasive method. [J]. Journal of Chongqing Medical University 36(1):77-80(2013)
DOI：

GU Sai, HUANG Miaoxing. Evaluation on hepatic fibrosis by joint non-invasive method. [J]. Journal of Chongqing Medical University 36(1):77-80(2013) DOI：

摘要

目的：建立适合临床推广的联合非创伤性评估非酒精性脂肪性肝病（non-alcoholic fatty liver disease，NAFLD）肝纤维化程度的方法和评估体系。方法：104例非酒精性脂肪性肝纤维化患者行病理分期，并测定肝纤维化相关标志物、金属蛋白酶1组织抑制剂（tissue inhibitors of matrix metalloproteinase-1，TIMP-1），B超及MR扩散加权成像（diffusion weighted imaging，DWI）。结果：B超与肝脏纤维化病理分级的相关系数为0.56，呈中等程度正相关，联合DWI、肝纤维化相关标志物及TIMP-1的非创伤性评估方法有高达84.69%正判率。结论：该联合评估方法是目前可操作性和可重复性好，值得推广的肝纤维化临床诊断方法之一。

Abstract

Objective：To establish a joint non-invasive clinical method and system to assess and evaluate the severity of hepatic fibro－sis of patiants with non-alcoholic fatty liver disease（NAFLD）. Methods：Totally 104 patients with non-alcoholic fatty hepatic fibrosis were divided according to different histopathological stages.Hepatic fibrosis relation indexes，tissue inhibitors of matrix metallopro－teinase-1（TIMP-1），hepatic B ultrasond and liver diffusion weighted imaging（DWI）were detected. Results：There were consider－able correlations between hepatic ultrasond and liver fibrosis grading，with a correlation coefficient of 0.56. Joint non-invasive method combing DWI，liver fibrosis markers and TIMP-1 corrected 84.69% of all trials. Conclusions：This joint non-invasive assessment method is practical and repeatable and is recommended to be a clinical method for diagnosing liver fibrosis.

关键词

非酒精性脂肪性肝病肝纤维化B超扩散加权成像评估

Keywords

non-alcoholic fatty liver diseasehepatic fibrosisB-ultrasonddiffusion weighted imagingestimation

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