Objective：To investigate the expressions of nuclear factor with BRCT domain 1（NFBD1） in nasopharyngeal carcinoma and their clinical significances. Methods：Expressions of NFBD1 protein in 40 cases of nasopharyngeal carcinoma（NPC）tissues and 20 cases of chronic nasopharyngitis tissues were detected by immunohistochemical SP method. Expressions of NFBD1 mRNA in 34 cases of NPC tissues and 23 cases of chronic nasopharyngitis tissues were observed by qRT-PCR and their correlations with patients’gen－der，age，cervical lymphnode metastasis and clinic stage were analyzed. Results：Expressions of NFBD1 protein and mRNA were sig－nificantly higher in NPC tissues than in chronic nasopharyngitis tissues（ ?字2=9.600，P=0.002；t=3.206，P=0.002）. Expressions of NFBD1 mRNA in NPC tissues were not significantly correlated with patient’gender（t=0.937，P=0.356），age（t=0.382，P=0.698），cervical lym－phnode metastasis（t=1.037，P=0.322） and clinic stage（t=0.293，P=0.771）. Conclusions：Overexpression of NFBD1 may be involved in the tumorigenesis of NPC，but it is not significantly correlated with nasopharyngeal carcinoma invasion and metastasis.