Expressions and clinical significances of circadian clock gene Per1 in patients with oral squamous cell carcinoma

ZHAO Chunrong; YANG Kai; ZHAO Ningbo; TANG Hong

您当前的位置：

首页 >

文章列表页 >

Expressions and clinical significances of circadian clock gene Per1 in patients with oral squamous cell carcinoma

更新时间：2023-12-18

- Expressions and clinical significances of circadian clock gene Per1 in patients with oral squamous cell carcinoma
- Journal of Chongqing Medical University Vol. 36, Issue 2, Pages: 130-133(2013)
- 作者机构：
  
  重庆医科大学附属第一医院口腔颌面外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2013，
扫描看全文
ZHAO Chunrong, YANG Kai, ZHAO Ningbo, et al. Expressions and clinical significances of circadian clock gene Per1 in patients with oral squamous cell carcinoma. [J]. Journal of Chongqing Medical University 36(2):130-133(2013)
DOI：

ZHAO Chunrong, YANG Kai, ZHAO Ningbo, et al. Expressions and clinical significances of circadian clock gene Per1 in patients with oral squamous cell carcinoma. [J]. Journal of Chongqing Medical University 36(2):130-133(2013) DOI：

摘要

目的：探讨生物钟基因Per1在口腔颊鳞癌组织中的表达及意义。方法：应用免疫组化SP法和Western blot法检测38例口腔颊鳞癌及其癌旁正常颊黏膜组织中Per1的表达情况，并结合临床病理指标进行探讨。结果：Per1在颊鳞癌中的表达显著低于在癌旁正常颊黏膜组织中的表达（P=0.025）。Per1在Ⅰ、Ⅱ期颊鳞癌中的表达显著高于在Ⅲ、Ⅳ期的表达（P=0.007），在T1、T2期颊鳞癌组织中的表达显著高于在T3、T4期中的表达（P=0.030），在无淋巴结转移者的表达显著高于在有淋巴结转移者中的表达（P=0.008），Per1的表达与患者性别、年龄及病理分级无明显相关性（P均大于0.05）。结论：Per1的表达在口腔鳞癌的发生发展，浸润、转移中可能占重要作用，为口腔颊鳞癌的诊断、预后评估和治疗提供了新的思路。

Abstract

Objective：To investigate the expressions and significances of circadian clock gene Per1 in patients with oral squamous cell carcinoma（OSCC）. Methods：Expressions of Per1 in 38 cases of buccal squamous cell carcinoma and the adjacent non-tumor tissues were examed by immunohistochemical SP method and Western blot method and the significances of Per1 were studied combined with the clinicopathological parameters. Results：Expressions of Per1 were significantly decreased in buccal squamous cell carcinoma tis－sues than in adjacent non-tumor tissues（P=0.025）. In buccal squamous cell carcinoma，expressions of Per1 were significantly higher in stageⅠ，Ⅱ period and T1，T2 grade than in stage Ⅲ，Ⅳ period and T3，T4 grade（P=0.007）（P=0.030），meanwhile the expressions of Per1 were significantly higher in group without lymph node metastasis than in group with lymph node metastasis（P=0.008）. Ex－pression of Per1 was in no correlation with patients’ gender，age and pathological grade（P >0.05）. Conclusions：Expression of Per1 may play an important role in the development，invasion and metastasis of patients with OSCC，and may provide a new way of thinking for OSCC diagnosis，prognosis assessment and treatment.

关键词

口腔鳞状细胞癌Per1免疫组织化学蛋白质印迹

Keywords

oral cavitysquamous cellcarcinomaPer1immunohistochemistryWestern blot

references

Views

517

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Circadian rhythm of oral squamous cell carcinoma in vivo

Tissue dynamic change in the carcinogenesis of the cheek pouch in golden hamster induced by DMBA

Expression and significance of FOXP3 in colon cancer cells

Expression of HIF-1α and Sema4D in pancreatic carcinoma and its clinical significance

Diagnostic values of serum tumor markers Cyfra 21-1,SCCAg,Ferritin,CEA,CA19-9 and AFP for oral/oropharyngeal squamous cell carcinomas

Related Author

YANG Kai

ZHAO Ningbo

CHEN Dan

ZHAO Dan

TANG Hong

ZHAO Chunrong

MEI Jie

et al

Related Institution

Department of Oral and Maxillofacial Surgery，The First Affiliated Hospital of Chongqing Medical University

Department of Oral and Maxillofacial Surgery,the First Affiliated Hospital,Chongqing Medical University

Department of Gastrointestinal Surgery,The Second People’s Hospital of Lianyungang City

Department of General Surgery,Handan Central Hospital

Department of Pancreatic Oncology,Tianjin Medical University Cancer Institute and Hospital

⁰