Objective：To investigate the effects of sinoaortic denervated（SAD） on the expressions of transient receptor potential canon－ical 3（TRPC3） channel and TRPC6 channel in the aorta of spontaneous hypertensive rats（SHR） and to discuss the relationship a－mong TRPC3，TRPC6 and blood pressure variability（BPV）. Methods：Fourteen male SHR at the age of 10 weeks were randomly di－vided into two groups：SAD operation group（n=7）and sham operation group（n=7）. 24 h blood pressure and BPV were measured in conscious，unrestrained rats at 8 weeks after operation. Expressions of messenger ribonucleic acid（mRNA）and protein of TRPC3 and TRPC6 were determined by RT-PCR，Western blot and immunohistochemistry staining respectively. Results：There was no difference in 24 h average systolic blood pressure（SBP） and diastolic blood pressure（DBP） between the two groups；24 h systolic blood pres－sure variability（SBPV） and diastolic blood pressure variability（DBPV） were significantly higher in SAD group than in sham opera－tion group（P<0.05），（P<0.01）；expressions of mRNA and protein of TRPC3 and TRPC6 were significantly higher in SAD group than in sham operation group（P<0.01）. Conclusions：SBPV and DBPV as well as mRNA and protein expressions of TRPC3 and TRPC6 of rats in SAD group are increased，indicating that the increased expressions of TRPC3 and TRPC6 are closely associated with ele－vated BPV and might be involved in the regulation of BPV.