Objective：To investigate the relationship between plasma copeptin，proadrenomedullin N-terminal 20 peptide （PAMP），N-terminal pro-brain natriuretic peptide（NT-proBNP） levels and severity of chronic heart failure（CHF）. Methods：Seventy-two patients with CHF and 32 non-CHF controls were enrolled. Plasma copeptin and PAMP concentrations were measured by ELISA and concen－tration of NT-proBNP was detected by triaged detection instrument. Cardiac structure and function were evaluated by color Doppler ultrasound. Results：Plasma copeptin and NT-proBNP levels were significantly higher in patients with CHF than in non-CHF controls（P<0.001），which were elevated with the increase of the New York heart association（NYHA） class. Concentration of copeptin was posi－tively correlated with left ventricular end-diastolic diameter（LVEDD） （r=0.508），serum creatinine（r=0.320），NYHA class（r=0.567），NT-proBNP（r=0.412） （all P<0.01） and was negatively correlated with left ventricular ejection fraction（r=-0.663，P<0.01）. There was no significant difference in terms of plasma PAMP levels between patients with CHF and non-CHF controls. Conclusions：Plasma copeptin and NT-proBNP levels are higher in patients with CHF and are closely related with the severity of CHF.