Objective：To evaluate the effects of sperm with different parameters on the outcomes of intracytoplasmic sperm injection（ICSI）. Methods：Totally 290 ICSI cycles were analyzed retrospectively. They were divided into 5 groups according to sperm parame－ters：group A（normal sperm forms or mild oligoastheno-teratozoospermia），group B（severe oligozoospermia），group C（severe astheno－zoospermia），group D（severe teratozoospermia），group E（severe oligoastheno-teratozoospermia）. Fertilization rate，cleavage rate，transferable embryos rate，good quality embryos rate，implantation and pregnancy rates were compared between the groups. Results：Fertilization rate，cleavage rate，transferable embryos rate and good quality embryos rate were not significantly different among the 5 groups（ χ2=1.27，P=0.87； χ2=1.34，P=0.86； χ2=0.56，P=0.97； χ2=1.39，P=0.85）. The chemical pregnancy rate，embryo implantation rate and clinical pregnancy rate were lower in group D and E than in group A（ χ2=12.1，P=0.00； χ2=10.15，P=0.00； χ2=10.78，P=0.00； χ2=9.90，P=0.00； χ2=8.13，P=0.00； χ2=11.78，P=0.00），B（ χ2=6.04，P=0.01； χ2=7.79，P=0.01； χ2=7.21，P=0.01； χ2=4.29，P=0.04； χ2=5.63，P=0.02； χ2=7.21，P=0.01）and C（ χ2=7.01，P=0.01； χ2=6.47，P=0.01； χ2=6.95，P=0.01； χ2=5.14，P=0.02； χ2=4.35，P=0.04； χ2=7.01，P=0.01）. Conclusions：Sperms of different parameters used in ICSI treatment can not affect the fertilization rate. Severe teratozoospermia can reduce the implantation and pregnancy rates after ICSI treatment.