Objective：To observe whether telephone guidance by specialists can improve the efficacy of the treatment for stable coronary heart disease or can reduce incidence of major cardiovascular events. Methods：Totally 200 patients with stable coronary heart disease were divided into telephone guidance group（n=100） and control group（n=100）. Patients in telephone guidance group re－ceived the specialists’ telephone guidance every 2 months. Indicators included the compliance of healthy life style，rate of taking cura－tive standard medicines，major cardiovascular events and patients’satisfaction degree. Results：Patient’s compliance of healthy life style，rate of taking curative standard medicines and patients’satisfaction degree were all higher in telephone guidance group than in control group（P＜0.05），but incidences of major cardiovascular events（myocardial infarction，readmission，revascularization of coro－nary artery，cardiac death） were lower in telephone guidance group than in control group（P<0.05）. Conclusions：Telephone guidance by specialists can improve the efficacy of the treatment for stable coronary heart disease and reduce incidence of major cardiovascular events.