Objective：To explore the relationship between expressions of Ezrin protein and distant metastasis of nasopharyngeal carci－noma（NPC）. Methods：Clinical data and biopsy samples of 76 patients with NPC were collected. Ezrin protein expressions were de－tected by immunohistochemical SP method. Kaplan-Meier method was used to calculate the metastasis risk and logistic regression analysis was applied to judge the risk factors of NPC distant metastasis. Results：Positive expression rate of Ezrin protein was 63.2% （48/76），which was positively correlated with lymph node metastasis and distant metastasis（P<0.05）. Logistic regression analysis showed that risk factors of distant metastasis in NPC included T stage，cervical lymph node metastasis and positive expression of Ezrin （P<0.05）. NPC patients with Ezrin positive expressions had higher metastasis risk（P<0.05）. Conclusions：Ezrin protein positive ex－pression is significantly related with metastasis of NPC and can be used as predictor of NPC distant metastasis.