Objective：To detect the expressions of hepatocyte growth factor（HGF）/c-Met system in nasal inverted papilloma and to explore the relationship between HGF/c-Met expressions and malignant transformation. Methods：Totally 30 cases of defined nasal in－verted papilloma and 12 cases of nasal malignant papilloma were chosen as experimental group while 28 cases of nasal polyps and 18 cases of chronic hypertrophic rhinitis were defined as control group. All samples were selected in our hospital from 2005 to 2010. Sur－gical treatment was applied to dissect the disease tissues，immunohistochemical SP was used to detect the expressions of HGF/c-Met and staining scores of the samples were calculated. HGF and c-Met mRNA level of removed tissues were detected by real-time PCR. Results：Statical score of experimental group was significantly higher than that of control group. In experimental group，score of malig－nant palilloma was higher than that of inverte papilloma. Real-time PCR results were similar to those of immunohistochemistry. Con－clusions：High expressions of HGF/c-Met may relate with malignant transformation of inverted papilloma. Detecting HGF/c-Met ex－pression may provide references for judging the malignant risk and prognosis of inverted papilloma.