Objective：To investigate the expressions of fibroblast growth factor 19（FGF19） and fibroblast growth factor receptor 4 （FGFR4） in esophageal squamous carcinoma and normal esophageal tissues and their correlation. Methods：Immunohistochemical method was used to detect the FGF19 and FGFR4 protein expressions in 34 postoperative pathological specimens of esophageal squa－mous carcinoma in patients in our hospital from 2009-2012 and normal esophageal tissues. Statistics analysis was made after the de－tection. Results：FGF19 and FGFR4 expressions were high in esophageal squamous carcinoma（P=0.000，P=0.000）. There was a posi－tive linear correlation between expressions of FGFR4 and FGF19 and lymph node metastasis（rs=0.401，P=0.019；rs=0.404，P=0.018） and pathological stage（rs=0.495，P=0.003；rs=0.439，P=0.009） in esophageal squamous carcinoma. Expressions of FGFR4 and FGF19 were in a positive linear correlation in the disease. Conclusions：FGF19 and FGFR4 proteins are correlated with esophageal squamous carcinoma and they participate in the process of invasion and metastasis.