Objective：To investigate the expression and clinicopathological significance of Ezrin protein in colorectal cancer with a sys－tematic review. Methods：Published studies were searched in EBSCO，EBMR+Journals，Pubmed，Wangfang databases，CNKI，VIP and quality of the included studies was assessed. Meta analysis of enrolled studies was performed by Reman 5.0 software. Results：Totally 14 studies were selected for this Meta analysis，including 1 383 colorectal caner cases and 298 normal controls. Results of Meta anal－ysis showed that ①There were significant differences in positive rate of Ezrin expression between colorectal cancer tissues and normal tissues（OR=15.72，95％CI=10.56 to 23.41，P=0.000）. ②Ezrin expression were associated with lymph node metastasis（OR=2.96，95％CI=1.69 to 5.19，P=0.000），Duke classification（OR=0.17，95％CI=0.08 to 0.37，P=0.000），infiltration depth（OR=0.56，95％CI=0.36 to 0.85，P=0.007），histological subtype（OR=0.37，95％CI=0.19 to 0.69，P=0.002） but not associated with sex（OR=1.19，95％CI=0.89 to 1.58，P=0.240），age（OR=1.15，95％CI=0.69 to 1.91，P=0.600），tumor length（OR=1.07，95％CI=0.66 to 1.73，P=0.790）. Conclusions：Expression of Ezrin in colorectal cancer is high. High expression of Ezrin may play an important role in metastasis of colorectal cancer.