Objective：To investigate the intervention role of invigorating the kidney and strengthening the bones therapy in controlling the pain after radiotherapy，reducing incidences of skeletal related events（SREs） and delaying time of recurrent bone metastasis for non-small cell lung cancer（NSCLC） patients with bone metastasis who received radiotherapy. Methods：Totally 59 NSCLC patients with bone metastasis were divided into two groups by randomization：treatment group（n=30） and control group（n=29）. Patients in treatment group were treated by radiotherapy and biphosphonates and received concurrent invigorating the kidney and strengthening the bones therapy（a traditional Chinese medicine therapy）；patients in control group were only treated by radiotherapy and biphos－phonates. Results：There were significant differences in the pain changes between two groups（treatment group P=0.002，control group P=0.001）. Incidences of SREs were lower in treatment group than in control group（P=0.036）. Time interval of recurrent bone metas－tasis was longer in treatment group than in control group，（24.81±1.99） weeks vs. （19.57±1.61） weeks，P=0.026. Conclusions：Invigorating the kidney and strengthening the bones therapy cannot reduce the pain of radiotherapy and biphosphonates，but can reduce the incidences of SREs and delay the time of recurrent bone metastasis.