Objective：To study the clinical efficacy of autologous peripheral blood hematopoietic stem cell transplantation（APBSCT） in the treatment of non-Hodgkin’s lymphoma（NHL）. Methods：A total of 56 patients who underwent APBSCT from February 2009 to October 2013 in the hospital were enrolled in the study. There were 37 males and 19 females with a median age of 44 years（16-69 years）；46 cases were in remission，7 cases in partial remission and 3 cases in relapsed or refractory. Results：Among 56 patients treated by APBSCT，55 patients obtained hematopoi－etic reconstitution. The median time for neutrophils recovery（＞0.5×109/L） was 9.5（7-18） d and platelet recovery（＞20×109/L） was 11.5（6-24） d. Twenty-four patients experienced fever during granulocyte lack phase，5 patients experienced mild-to-moderate diarrhea，one patient had mild liver function damage and one patient had herpes zoster. All patients were followed up till the 1st April，2014，and the median follow-up time was 20.25（3-60.5） months. Forty-five cases survived（5 cases alive with disease）；10 cases relapsed；11 cases died（5 cases died of recurrence）. The recurrence rate was 17.9%. Overall survival and disease-free survival were 80.4% and 71.4% respectively. Conclusion：With the advantages of quicker hematopoietic reconstruction and fewer non-Hodgkin’s lymphoma，APBSCT is effective in the treatment of NHL.