Effects of perindopril on bFGF-2 expression in isoproterenol-induced myocardial hypertrophy of rats

Xin Ying; Zhao Yulan; Dong Jing; Huang Yaping

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Effects of perindopril on bFGF-2 expression in isoproterenol-induced myocardial hypertrophy of rats

更新时间：2023-12-18

- Effects of perindopril on bFGF-2 expression in isoproterenol-induced myocardial hypertrophy of rats
- Journal of Chongqing Medical University Vol. 38, Issue 5, Pages: 630-633(2014)
- 作者机构：
  
  郑州大学第二附属医院心内科,郑州,450014
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2014，
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Xin Ying, Zhao Yulan, Dong Jing, et al. Effects of perindopril on bFGF-2 expression in isoproterenol-induced myocardial hypertrophy of rats. [J]. Journal of Chongqing Medical University 38(5):630-633(2014)
DOI：

Xin Ying, Zhao Yulan, Dong Jing, et al. Effects of perindopril on bFGF-2 expression in isoproterenol-induced myocardial hypertrophy of rats. [J]. Journal of Chongqing Medical University 38(5):630-633(2014) DOI：

摘要

目的：探讨培哚普利片对异丙肾上腺素（isoproterenol，ISO）所致心肌肥厚大鼠碱性成纤维细胞生长因子-2（basic fi－broblast growth factor，bFGF-2）表达的影响。方法：将研究大鼠分为对照组、模型组及药物干预组，对照组大鼠背部行皮下注射生理盐水；模型组大鼠皮下注射ISO；药物干预组大鼠皮下注射ISO，培哚普利片灌胃，称量计算各组大鼠左心室质量/体质量（left ventricular mass/body mass，LVM/BM）和全心质量/体质量（heart mass/body mass，HM/BM）并进行对比，应用免疫组化及逆转录聚合酶链反应（reverse transcription polymerase chain reaction，RT-PCR）的方法比较各组大鼠左心室中bFGF-2含量、3组大鼠LVM/BM和HM/BM。结果：大鼠LVM/HM、HM/BM比较，对照组

Abstract

Objective：To explore the effect of perindopril on basic fibroblast growth factor（bFGF-2） expression in isoproterenol（ISO）-induced cardiac hypertrophy of rats. Methods：The research rats were randomly divided into three groups and 10 rats in each group：control group，model group（3mg/（kg·d） isoproterenol for 10 d） and intervention group（3 mg/（kg·d） isoproterenol and 1 mg/（kg·d） perindopril for 10 d）. Left ventricular mass/body mass（LVM/BM） and heart mass/body mass（HM/BM） were detected and compared；in addition，FGF-2 mRNA and protein in left ventricular tissues were analyzed by RT-PCR and immunohistochemistry. Results：Results of LVM/BM and HM/BM in the 3 groups were：control group

关键词

心肌肥厚碱性成纤维细胞生长因子-2培哚普利逆转录聚合酶链反应

Keywords

cardiac hypertrophybasic fibroblast growth factorperindoprilreverse transcription polymerase chain reaction（RT-PCR）

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