Objective：To analyze the risk factors for adverse perinatal outcomes of twins. Methods：The 251 cases of twin pregnancy in obstetric unit of Chongqing Health Center for Women and Children from January 1 2013 to December 31 2013 were enrolled in the retrospective study. Results：（1）The incidence of adverse perinatal outcomes of twins in the hospital was approximately 34.66%. The incidence of perinatal death was 8.37%.Single factor analysis：there were significant differences in fertilization way，chorionicity，preterm premature rupture of membranes，gestational diabetes（P<0.05）. （3）Logistic regression analysis：cescarean section is a protec－tive factors for perinatal outcomes of twins（P=0.000，OR=0.086，95%CI=0.023 to 0.321）. Preterm premature rupture of membranes（PPROM） and monochrionic twins are risk factors for adverse perinatal outcome（P=0.010，OR=2.979；P=0.043，OR=5.689）. Con－clusion：PPROM，monochorionic are the main risk factors for adverse perinatal twins while cesarean section is the protective factor.