Protective effect of Mrh-aFGF on the neurons in ventral tegmental area of rats with Parkinson disease

XIAO Chun-gou; JIANG Wei; LI Li-qiang; ZOU Jin-hui; SHEN Wei-zai

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Protective effect of Mrh-aFGF on the neurons in ventral tegmental area of rats with Parkinson disease

更新时间：2023-05-22

- Protective effect of Mrh-aFGF on the neurons in ventral tegmental area of rats with Parkinson disease
- null Issue 8, Pages: 551(2016)
- 作者机构：
  
  1. 1．肇庆医学高等专科学校解剖学教研室,广东,肇庆,526020
  2. 2．暨南大学医学院解剖学教研室,广东,广州,510632
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2016，
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XIAO Chun-gou, JIANG Wei, LI Li-qiang, et al. Protective effect of Mrh-aFGF on the neurons in ventral tegmental area of rats with Parkinson disease. [J]. null (8):551(2016)
DOI：

XIAO Chun-gou, JIANG Wei, LI Li-qiang, et al. Protective effect of Mrh-aFGF on the neurons in ventral tegmental area of rats with Parkinson disease. [J]. null (8):551(2016) DOI：

摘要

[摘要]目的探讨重组人改构体酸性成纤维细胞生长因子(Mrh-aFGF)对帕金森病（PD）大鼠中脑腹侧被盖区神经元病变的影响。方法将54只SPF级雄性SD大鼠随机分为对照组、模型组和治疗组，每组18只。6-OHDA分别注入大鼠左侧黑质和中脑腹侧被盖区后建立PD模型，侧脑室内注射Mrh-aFGF，用阿扑吗啡诱导旋转行为；Nissl染色法观察大鼠中脑腹侧被盖区神经元病理学改变；电子显微镜观察中脑腹侧被盖区神经元及突触超微结构的变化。结果模型组大鼠损毁侧中脑腹侧被盖区神经元数目较健侧明显减少(P<0.05)；治疗组术后1周、2周、4周损毁侧神经元数目均较模型组明显增加(P<0.05)；模型组大鼠中脑腹侧被盖区神经元超微结构明显受损，出现核固缩，粗面内质网扩张、脱颗粒，线粒体肿胀、嵴消失，以及突触前后膜肿胀、突触间隙消失，治疗组中脑腹侧被盖区神经元超微结构有明显改善。结论Mrh-aFGF能减少PD大鼠中脑腹侧被盖区神经元的丢失，并改善其神经元的超微结构。

Abstract

关键词

帕金森病重组人改构体酸性成纤维细胞生长因子中脑腹侧被盖区超微结构大鼠

Keywords

Parkinson diseasemodified recombinant human acid fibroblast growth factorventral tegmental areaultrastructurerat

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