Clinical significance and gene enrichment analysis of BMI1 gene in patients with hepatocellular carcinoma

JIANG Aijun; WANG Hong; CHE Helong; ZHANG Kun; YANG Hejun; HUANG Rong

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Clinical significance and gene enrichment analysis of BMI1 gene in patients with hepatocellular carcinoma

更新时间：2023-05-22

- Clinical significance and gene enrichment analysis of BMI1 gene in patients with hepatocellular carcinoma
- null Issue 6, Pages: 455(2019)
- 作者机构：
  
  1. 解放军联勤保障部队第908医院普通外科,江西,鹰潭,335000
  2. 解放军联勤保障部队第900医院肝胆外科,福建,福州,350025
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2019，
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JIANG Aijun, WANG Hong, CHE Helong, et al. Clinical significance and gene enrichment analysis of BMI1 gene in patients with hepatocellular carcinoma. [J]. null (6):455(2019)
DOI：

JIANG Aijun, WANG Hong, CHE Helong, et al. Clinical significance and gene enrichment analysis of BMI1 gene in patients with hepatocellular carcinoma. [J]. null (6):455(2019) DOI：

摘要

目的探讨B细胞特异的莫洛尼白血病毒插入位点1基因(BMI1)在肝细胞癌（HCC）中表达上调及其与患者预后的关系。方法生物信息学分析BMI1与肝癌患者的临床资料及预后的关系。采用实时定量PCR检测HCC组织中BMI1表达情况，验证BMI1表达水平与患者临床病理学特征关系。从GEO数据库中下载肝癌基因表达数据GSE56140，分析BMI1高表达在HCC中的生物学功能。结果 linkedomics在线分析结果显示，BMI1与377例肝癌患者的病理学N分期、种族、总生存期具有相关性（P<0.05），BMI1主要表达于细胞核中。Kaplan-Meier plotter分析结果为HR=1.46

95%CI:1~2.13

log rank P=0.048。BMI1高表达组与低表达组相比，差异具有统计学意义（P<0.05）；BMI1的高表达组与肿瘤直径、血管侵犯、TNM分期、Edmonson分级、肿瘤无包膜显著相关，差异有统计学意义（P<0.05）。Kaplan-Meier结果显示BMI1高表达的HCC患者预后比BMI1低表达的患者预后差；基因富集分析结果显示BMI1可能通过细胞周期、RNA降解、剪接体、DNA复制、氧化磷酸化、错配修复等生物学过程促进肝癌细胞增殖。结论 BMI1可能参与HCC的发生和发展过程，并与预后相关。

Abstract

Objective To investigate the upregulation of BceIlspecific Moloney murine leukemia virus integration site1 (BMI1) in hepatocellular carcinoma (HCC) and its relationship with prognosis. Methods Bioinformatics was used to analyze the correlation between BMI1 and clinical data of patients with liver cancer.Realtime quantitative PCR was used to verify the expression of BMI1 in HCC tissues

and the relationship between BMI1 expression level and clinicopathological features was analyzed.The liver cancer gene expression data GSE56140 was downloaded from GEO database to analyze the biological function of BMI1 high expression in HCC. Results The online analysis of linkedomics showed that BMI1 was associated with pathological N stage

race and overall survival of 377 patients with HCC(P<0.05);BMI1 was mainly expressed in the nucleus.The KaplanMeier plotter analysis showed:HR=1.46

95%CI:1~2.13 and log rank P=0.048.The difference between the BMI1 high expression group and the low expression group was statistically significant(P<0.05).At the same time

the high expression group of BMI1 was significantly associated with tumor size

vascular invasion

TNM stage

Edmonson classification

tumorfree capsule

and the difference was statistically significant(P<0.05).KaplanMeier results showed that patients with high expression of BMI1

the prognosis was worse than that of patients with low BMI1 expression.Gene enrichment analysis indicated that BMI1 may promote malignant transformation of liver cancer cells via cell cycle

RNA degradation

splice

DNA replication

oxidative phosphorylation

mismatch repair and other biological processes.Conclusion BMI1 may be involved in the occurrence and development of HCC and is associated with disease prognosis in HCC patients.

关键词

肝细胞癌BMI1临床表型预后基因富集分析

Keywords

hepatocellular carcinomaBMI1clinical phenotypeprognosisgeneenrichment analysis

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