Objective To investigate the diagnostic value of cervical vascular color Doppler ultrasound（CUS） combined with transcranial Doppler ultrasound（TCD） on ischemic stroke in the context of emergency access. Methods Eighty patients with ischemic stroke admitted to Zhengzhou People’s Hospital from Feb. 2020 to Feb. 2021 were selected as subjects in the observation group

and another 80 patients with non-ischemic stroke were selected as controls in the control group. All patients were examined by CUS and TCD under emergency access. The proportion of carotid artery intima-media thickening

the severity of carotid artery stenosis and intracranial artery stenosis were compared between the two groups

and the diagnostic efficacy of the two examination methods alone and in combination for ischemic stroke was calculated. Results Carotid artery intima-media thickening of the patients in the observation group（91.25%） was significantly higher than that in the control group（30.00%

P<0.05）. There were statistically significant differences in carotid artery stenosis and intracranial artery stenosis between the two groups（all P<0.05）. The proportion of patients with moderate to severe carotid artery stenosis and the proportion of patients with moderate to severe intracranial artery stenosis in the observation group were higher than those in the control group. The sensitivity

specificity

and accuracy of CUS were 75.00%

65.00%

and 70.00%

respectively. The sensitivity

specificity

and accuracy of TCD were 71.25%

66.25%

and 68.75%

respectively. The sensitivity

specificity

and accuracy of TCD were 93.75%

90.00%

and 91.88%

respectively. The sensitivity

specificity

and accuracy of the combination of the two procedures were significantly higher（all P<0.05）. Conclusion CUS combined with TCD has good diagnostic efficacy for ischemic stroke

which can assist physicians to observe the carotid artery and intracranial artery stenosis and provide reliable evidence for clinical diagnosis. These benefits hold much promise for a wider application of this procedure clinically.