Objective To investigate the clinical effect of intermittent hemodialysis（IHD） combined with ulinastatin in the treatment of septic patients with acute kidney injury（S-AKI） to provide guidance for clinical treatment. Methods A total of 55 patients with S-AKI admitted to the First Affiliated Hospital of Henan University of Science and Technology from June 2015 to June 2020 were selected as the study subjects. The participants were allocated into an observation group（n=27） and a control group（n=28） by a random number table. Patients in the control group received IHD via a hemodialysis machine

and patients in the observation group received IHD in combination with ulinastatin. ICU length of stay

duration of device ventilation

and the number of on-treatment deaths were compared between the 2 groups. Serum creatinine（Scr）

blood urea nitrogen（BUN）

interleukin-6（IL-6）

interleukin-8（IL-8）

and high-sensitivity C-reactive protein（hs-CRP） levels were compared between the 2 groups before treatment and 1 month after treatment. Results The ICU admission time and device ventilation time in the observation group were shorter than those in the control group

and the differences were statistically significant（P<0.05）. There was no significant difference in mortality between the 2 groups（P>0.05）. Before treatment

there were no significant differences in IL-6

IL-8

hs-CRP

Scr

and BUN levels between the 2 groups（P>0.05）. One month after treatment

the levels of IL-6

IL-8

hs-CRP

Scr and BUN in the two groups were lower than those before treatment

and the observation group was lower than the control group

with statistically significant differences（P<0.05）. Conclusion IHD in combination with ulinastatin shows established effects in the treatment of S-AKI. It can effectively enhance the immune function and renal function

promote rehabilitation

and improve the prognosis of patients. These benefits hold promise for a wider application of this technique clinically.