Objective To explore the effect of systematic holistic nursing in perioperative nursing of laparoscopic radical gastrectomy for gastric cancer（GC）. Methods A total of 81 patients with GC treated with laparoscopic radical gastrectomy in a hospital in Nanyang City from January 2018 to January 2020 were selected as subjects

and were assigned to a study group（n=41） and a control group（n=41） using the random number table method. The patients in the study group received systematic holistic nursing interventions during the perioperative period and the patients in the control group received routine nursing interventions during the perioperative period. The patients in both groups received continuous intervention for 3 weeks. The Hamilton Depression Scale（HAMD） scores

Activity of Daily Living（ADL） Scale scores and Hamilton Anxiety Scale（HAMA） scores were compared before and after the intervention

and the patients’ satisfaction with nursing and complications during nursing were compared. Results Before the intervention

there was no statistically significant difference in the HAMA and HAMD scores of the two groups（P>0.05）. After the intervention

the HAMA and HAMD scores of the 2 groups were lower than those before the intervention

and the study group was lower than the control group

with statistically significant differences（P<0.05）. Before the intervention

there was no significant difference in advanced ability

basic ability and ADL total scores between the two groups（P>0.05）. After the intervention

the advanced ability

basic ability and ADL total scores of the two groups were higher than those before the intervention

and the study group was higher than the control group

with statistical significance（P <0.05）. The nursing satisfaction of patients in the study group was 97.56%

which was higher than that in the control group（82.50%）

and the difference was statistically significant（P<0.05）. The incidence of complications during nursing in the study group was 4.88%

which was lower than that in the control group（20.00%）

and the difference was statistically significant（P<0.05）. Conclusion The effect of systematic holistic nursing in the perioperative period of laparoscopic radical gastrectomy for patients with GC is exact

which can effectively reduce the negative emotions

improve the quality of life and reduce the risk of complications of patients in the perioperative period. It thus has broad application prospects.