Objective To investigate the influencing factors and nursing intervention of negative mentality in pregnant women underwent in vitro fertilization-embryo transfer（IVF-ET）. Methods A total of 230 pregnant women with successful IVF-ET assisted conception admitted to a hospital in Henan Province from January to December 2020 were selected as subjects. They were assigned to a negative mentality group（n=94） and a non-negative mentality group（n=136） based upon whether the pregnant women had combined negative mentality [anxiety and/or depression]. The general data of pregnant women in the 2 groups were collected

including age

place of residence

education level

history of miscarriage or abortion

years of infertility

husband’s attitude toward IVF-ET treatment

occupation

cost of treatment for infertility

and public pressure. Multi-factor logistic regression was adopted to analyze the risk factors for negative mentality among pregnant women with IVF-ET. Results A total of 94 subjects with negative mentalities were found among 230 subjects underwent IVF-ET

and the detection rate of negative mentalities was 40.87%. Among them

56 pregnant women showed anxiety

with a detection rate of 24.35% and a SAS score of（55.23±2.26）; 38 pregnant women showed depression

with a detection rate of 16.52% and a SDS score of（57.51±1.29）. The results of multi-factor logistic regression analysis showed that the husband’s attitude toward IVF-ET treatment was neutral

the cost of treating infertility over 30

000 yuan and public pressure were risk factors for negative mentalities in pregnant women underwent IVF-ET（P<0.05）. Conclusion The husband’s neutral attitude toward IVF-ET treatment

the cost of infertility treatment over 30

000 RMB

and high public pressure were risk factors for negative mentalities among pregnant women underwent IVF-ET

and targeted nursing interventions for pregnant women underwent this procedure can be provided clinically to prevent the emergence of negative mentalities among them.