Objective To investigate the effect of the web-based chronic disease management model in combination with modified Bushen Yiliu decoction therapy in the treatment of patients with prostate cancer combined with type 2 diabetes mellitus（T2DM）. Methods A total of 160 patients with prostate cancer combined with T2DM admitted to a hospital in Henan Province from December 2020 to December 2021 were selected as subjects

who were assigned to an observation group and a control group via the random number table method

with 80 cases in each group. Patients in the control group received conventional treatment and modified Bushen Yiliu decoction for 3 months. Patients in the observation group received web-based chronic disease management in addition to the therapy in the control group. The overall efficacy

survival time

disease progression time

and T2DM Self-Care Scale（2-DSCS） scores of patients in the 2 groups were compared. Results The objective remission rate（ORR） and disease control rate（DCR） of patients in the observation group were higher than those in the control group

and all differences were statistically significant（P<0.05）. The survival time of patients in the observation group was（41.26±8.24） months

which was higher than that of the control group（30.11±7.83） months

and the difference was statistically significant（P<0.05）. The scores of dietary self-management

regular exercise

medication compliance

foot care

high and low blood sugar prevention and control in the 2-DSCS of patients in the observation group were higher than those in the control group at weeks 1 and 3 after treatment

and the differences were statistically significant（P<0.05）. Conclusion The Web-based chronic disease management in combination with modified Bushen Yiliu decoction therapy in the treatment of patients with prostate cancer combined with T2DM has established effects and can effectively improve ORR

DCR and patients’ survival time

as well as improve patients’ self-care

demonstrating marked clinical efficacies. These benefits justify a wider application of this therapy clinically.