Objective To investigate the clinical efficacy of dopamine combined with recombinant human erythropoietin（rh EPO） in the treatment of neonatal sclerosis. Methods A total of 112 newborns with sclerosis admitted to a hospital in Panjin from January 2017 to January 2021 were selected as subjects

who were assigned to a rh EPO group and a control group using the random number table method

with 56 cases in each group. The children in the control group were treated with dopamine

and the children in the rh EPO group dopamine combined with rh EPO. The children in both groups were treated for 7 d and received a follow-up for 6 months. The clinical efficacy

the time to initial scleromas resolution

the time to complete resolution of the scleromas

and rewarming time were compared. The serum creatinine（SCr） and blood urea nitrogen（BUN） levels before and after treatment were compared between the two groups of children. The psychomotor development index（PDI） scores and mental development index（MDI） scores of the two groups were compared at 3 months and 6 months of follow-up. Results The total effective rate of treatment for children in the rh EPO group was 98.21%

which was higher than that of the control group（85.71%）

and the difference was statistically significant（P<0.05）. The time to initial scleromas resolution

the time to complete resolution of the scleromas

and rewarming time in the rh EPO group were shorter than those in the control group

and the differences were statistically significant（P<0.05）. After treatment

the serum BUN levels of children in both groups were lower than those before treatment

and the rh EPO group was lower than the control group

with statistically significant differences（P<0.05）. The MDI and PDI scores of children in the rh EPO group were higher than those in the control group at 3 and 6 months of follow-up

and the differences were statistically significant（P<0.05）. Conclusion Dopamine in combination with rh EPO is effective in the treatment of neonatal sclerosis

which can effectively improve the renal function of the children

promote the recovery of the disease

and promote the intelligent development of the children. These benefits justify a wider application of this procedure clinically.