Objective To investigate the effects of the preemptive analgesia of dexmedetomidine combined with parecoxib sodium on the pain level and inflammatory factors of elderly patients after hip fracture surgery.Methods Ninety-three elderly hip fracture patients who received surgical treatment in a hospital in Zhengzhou from July 2019 to March 2021 were enrolled for the study and divided into a control group（n=46） and an observation group（n=47） by a random number table.Patients in the observation group were infused with dexmedetomidine combined with parecoxib sodium before anesthesia

and patients in the control group were infused with the same volume of saline before anesthesia.The pain level as indicated by visual analog scale（VAS） scores

the levels of inflammatory factors interleukin-1β（IL-1β） and interleukin-6（IL-6） as well as the levels of stress hormones cortisol（CORT） and norepinephrine（NE） were compared between the 2 groups of patients at different time points after surgery.Results In the immediate postoperative period

there was no statistically significant difference between the VAS scores of patients in the 2 groups（P>0.05）;at 6 h and 24 h after surgery

the VAS scores of patients in the observation group were lower than those in the control group

and the differences were statistically significant（P<0.05）.In the immediate postoperative period

the differences between the IL-1β and IL-6 levels in the 2 groups were not statistically significant（P>0.05）;at 6 h and 24 h after surgery

the IL-1β and IL-6 levels in the observation group were lower than those in the control group

with statistically significant differences（P<0.05）.In the immediate postoperative period

there was no statistically significant difference between the CORT and NE levels in the 2 groups（P>0.05）;at 6 h and 24 h after surgery

the CORT and NE levels of the observation group were lower than those of the control group

and the differences were statistically significant（P<0.05）.Conclusion The preoperative application of dexmedetomidine combined with parecoxib sodium as preemptive analgesia for elderly hip fracture patients can effectively reduce the postoperative pain level and decrease the elevation of inflammatory factors and stress hormone levels

and thus has high value for clinical practice.