Objective To explore the effects of humanistic care nursing in the care of post-stroke depression. Methods One hundred and twenty-six cases of post-stroke depression patients admitted to a hospital in Pingdingshan from October 2019 to October 2020 were selected as the study subjects and were divided into a control group and a study group according to different nursing methods

with 63 cases in each group. The patients in the control group were given conventional care and the patients in the study group were given humanistic care

and the patients in both groups were continuously cared for 8 weeks. The modified Barthel Index（MBI）

National Institutes of Health Stroke Scale（NIHSS）

Hamilton Depression Rating Scale（HAMD）

Self-Rating Depression Scale（SDS） and Self-Rating Anxiety Scale（SAS） scores were compared between the two groups before and after care

and the compliance rates during care compared between the two groups. Results Before care

there was no statistically significant difference between the HAMD

MBI and NIHSS scores of the two groups（P>0.05）; after care

the HAMD and NIHSS scores of the two groups were lower than before care

and those of the study group were lower than those of the control group

with statistically significant differences（P<0.05）; after care

the MBI scores of the two groups were higher than before care and higher in the study group than in the control group

and the differences were statistically significant（P<0.05）. The compliance rate of patients in the study group was 96.8% during care

which was higher than that of 82.6% in the control group

and the difference was statistically significant（χ2=5.489

P=0.019）. Before care

there was no statistically significant difference in SDS and SAS scores between the 2 groups（P >0.05）; after care

SDS and SAS scores were lower in both groups than before care and lower in the study group than in the control group

with statistically differences（P<0.05）. Conclusion Humanistic care for patients with post-stroke depressed can improve the nursing effect

improve negative emotions and enhance self-care ability

and is worth promoting in clinical practice.