Objective To explore the clinical application value of integrated medical and nursing care intervention based on the concept of fast track surgery（FTS） in the perioperative period of colorectal cancer patients.Methods Eighty-one patients with colorectal cancer treated with surgery in a hospital in Nanyang city from January 2019 to November 2020 were selected as the study subjects

and were divided into the study group（41 cases） and the control group（40 cases） using the random number table method.Patients in the control group were given conventional nursing care while patients in the study group received integrated medical and nursing care intervention based on the FTS concept;the treatment in both groups lasted for 7 days.The levels of motilin（MT）

somatostatin（SS） and d-lactate（D-LA）

and the scores of self-rating anxiety scale（SAS） and self-rating depression scale（SDS） were compared before and after care

and the occurrence of complications was compared between the two groups.Results Before care

serum MTL

SS and D-LA levels of patients in the 2 groups were compared

and the differences were not statistically significant（P>0.05）.After care

the serum MTL levels of patients in the 2 groups were higher than before care

and the study group was higher than the control group

with statistically significant differences（P<0.05）;the D-LA levels were higher than before care

but the study group was lower than the control group

and the differences were statistically significant（P <0.05）;the SS levels were higher than before care

and the differences were statistically significant（P<0.05）

but the differences between the groups were not statistically significant（P>0.05）.Before care

the differences in SDS and SAS scores were not statistically significant（P >0.05） when compared between the 2 groups.After care

the SDS and SAS scores of patients in the study group were lower than those in the control group

and the differences were all statistically significant（P<0.05）.The complication rate of patients in the control group was 17.50%

which was higher than that of 4.88% in the study group

but the difference was not statistically significant（χ~2=3.608

P=0.058）.Conclusion The integrated medical and nursing intervention based on the FTS concept can effectively improve the negative perioperative emotions of colorectal cancer surgery patients and promote the recovery of postoperative gastrointestinal function

which can be promoted and applied in clinical practice.