Objective To analyze the effects of high-flux hemodialysis treatment on calcium and phosphorus metabolism and recent prognosis in patients with chronic renal failure（CRF）. Methods Seventy-nine patients with CRF admitted to a hospital in Zhengzhou from March 2018 to July 2020 were selected as study subjects and divided into study group（n=43） and control group（n=36） according to treatment method. Patients in the study group were given high-flux hemodialysis treatment and patients in the control group were given conventional hemodialysis treatment

both of which were continued for 12 weeks. The clinical efficacy

dialysis adequacy [urea clearance index（KT/V）

time-averaged urea concentration（TACurea） and normalized protein catabolic rate（n PCR）] and near-term prognosis of the patients in the 2 groups were compared

and the calcium and phosphorus metabolism levels

parathyroid hormone（PTH） levels and renal function indexes [β2-microglobulin（β2-MG）

serum creatinine（SCR）

blood urea nitrogen（BUN）]

of patients before and after treatment were compared as well. Results The total effective rate of treatment in the study group was 90.70%

which was higher than that of the control group（72.22%）

and the difference was statistically significant（χ

2

=4.587

P=0.032）. Before treatment

there was no statistically significant difference between the levels of blood calcium

blood phosphorus and PTH between the 2 groups（P

>

0.05）. After treatment

the blood calcium levels of both groups were higher than before treatment

and the study group was higher than the control group

and the differences were statistically significant（P

<

0.05）; the blood phosphorus and PTH levels were lower than before treatment

and the study group was lower than the control group

and the differences were statistically significant（P

<

0.05）. Before treatment

there were no statistically significant differences in the levels of β2-MG

SCR and BUN between the 2 groups（P

>

0.05）. After treatment

the levels of β2-MG

SCR and BUN in both groups were lower than those before treatment

and the study group was significantly lower than the control group

and the differences were statistically significant（P

<

0.05）. After treatment

there was no statistically significant difference in TACurea between the 2 groups（P

>

0.05）; however

the n PCR of patients in the study group was lower than that of the control group

and the KT/V was higher than that of the control group

and the differences were all statistically significant（P

<

0.05）. Among the patients in the study group

patients without pruritus were significantly more than the control group

and patients with moderate pruritus were significantly less than the control group

and all differences were statistically significant（P

<

0.05）. By the end of follow-up

the mortality rate of patients in the study group was 13.95%

and it was significantly lower than that of the control group（33.33%

P

<

0.05）. Conclusion High-flux hemodialysis treatment can improve the residual renal function of CRF patients

maintain the balance of calcium and phosphorus metabolism

and improve the near-term prognosis of patients

which is worthy of clinical promotion and application.