Objective To explore the risk factors of nephrotic syndrome（NS） complicated by lower limb deep vein thrombosis（LDVT） and related nursing countermeasures. Methods One hundred patients with NS complicated by LDVT admitted to a hospital in Nanyang from May 2018 to May 2020 were selected as the study group

and another 100 patients who were hospitalized with NS uncomplicated by LDVT in the same period were selected as the control group. The general data of patients in the 2 groups were collected

including their gender

age

education

occupation

and history of alcohol consumption. Multi-factor logistic regression analysis was used to analyze the risk factors affecting NS complicated with LDVT. Results The proportion of patients in the study group with limb mobility impairment

indwelling venous line

history of alcohol consumption

history of diabetes mellitus

history of hypertension

history of hyperlipidemia

history of surgery

and history of varicose veins was higher than that in the control group

while their PLT and TC levels were lower than those in the control group

and FIB

BUN

and SBP levels were higher than those in the control group. All differences were statistically significant（P<0.05）. Limb mobility impairment

presence of indwelling venous line

history of alcohol consumption

history of diabetes mellitus

history of hypertension

history of hyperlipidemia

history of surgery

history of varicose veins

high PLT level

and high SBP level were independent risk factors for NS complicating LDVT. Conclusion Risk factors for NS complicating LDVT include limb mobility impairment

presence of indwelling venous line

history of alcohol consumption

history of diabetes mellitus

history of hypertension

history of hyperlipidemia

history of surgery

history of varicose veins

high PLT level

and high SBP level. Targeted nursing interventions can be performed clinically to prevent NS complicating LDVT based on the results of the analysis.