Objective To explore the active molecules in Qibai ointment and their mechanism in the treatment of aestates. Methods Potential active molecules was screened out using Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. The targets related to aestates was explored in Genecards database. Then

the network of active molecules and targets of aestates was pictured. String database platform was used to calculate PPI core genes. Finally

Metascape database was using to perform GO enrichment analysis and KEGG enrichment analysis. Results There were 12 potential active molecules in Qibai ointment and 45 genes related to aestates

including IL6

PTGS2

TNF

AKT1

JUN and so on.quercetin

kaempferol

（+）-catechin were key active substances.The results of enrichment analysis showed that IL-17 signaling pathway was the possible key pathway of Qibai ointment in the treating aestates.The results of molecular docking indicated that the molecular interaction between key active substances and targets was strong.Conclusion Quercetin

kaempferol

（+）-catechin in Qibai ointment can treat aestates through IL-17 signaling pathway via many biological processes.