Expression of miR-1231 and miR-146b in ovarian cancer and their relationship with patient prognosis

MIAO Jing; GAO Li-feng; SUN Meng-xiong; LIU Nan; ZHANG Hong-qing; WANG Zhi-hua

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Expression of miR-1231 and miR-146b in ovarian cancer and their relationship with patient prognosis

更新时间：2022-11-04

- Expression of miR-1231 and miR-146b in ovarian cancer and their relationship with patient prognosis
- null Issue 5, Pages: 419(2022)
- 作者机构：
  
  1. 张家口市第一医院妇产科,河北,张家口,075000
  2. 张家口市第一医院检验科,河北,张家口,075000
  3. 张家口市第一医院病理科,河北,张家口,075000
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MIAO Jing, GAO Li-feng, SUN Meng-xiong, et al. Expression of miR-1231 and miR-146b in ovarian cancer and their relationship with patient prognosis. [J]. null (5):419(2022)
DOI：

MIAO Jing, GAO Li-feng, SUN Meng-xiong, et al. Expression of miR-1231 and miR-146b in ovarian cancer and their relationship with patient prognosis. [J]. null (5):419(2022) DOI：

摘要

目的探讨卵巢癌组织中miR-1231、miR-146b的表达情况，并分析二者与患者预后的关系。方法选取我院收治的141例行卵巢癌根治术的患者作为卵巢癌组，取同期行腹腔镜手术治疗的69例良性卵巢组织病变患者作为对照组。比较2组患者组织中miR-1231、miR-146b表达水平。术后随访3年，根据卵巢癌患者预后分成预后良好组、预后不良组，单因素分析卵巢癌患者预后不良的相关因素，并经Cox多元回归模型分析卵巢癌患者预后不良的危险因素。绘制Kaplan Meier生存曲线，经log-rank χ2检验分析不同miR-1231、miR-146b表达患者预后的差异。结果卵巢癌组miR-1231、miR-146b mRNA相对表达水平低于对照组（P＜0.05）。预后不良组低分化、国际妇产科联盟（FIGO）分期Ⅲ～Ⅳ期、淋巴结转移的占比高于预后良好组，术后放/化疗及miR-1231、miR-146b高表达的占比低于预后良好组（P＜0.05）。Cox多元回归分析显示低分化、FIGO分期Ⅲ～Ⅳ期、淋巴结转移是卵巢癌患者预后不良的危险因素，术后放/化疗及miR-1231、miR-146b高表达是预后的保护因素（P＜0.05）。miR-1231、miR-146b高表达组3年累积生存率高于miR-1231、miR-146b低表达组（P＜0.05）。结论卵巢癌组织中miR-1231、miR-146b表达降低，二者低表达会增加卵巢癌患者的预后不良风险。

Abstract

关键词

卵巢癌miR-1231miR-146b预后危险因素微小核糖核酸

Keywords

ovarian cancermiR-1231miR-146bprognosisrisk factorsmicroRNA

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