Expression of PD-1 and TIM-1 in non-small cell lung cancer and their effects on prognosis

CHEN Can; ZHENG Lin-xin; MAI Yu-mei; LI Wei-feng

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Expression of PD-1 and TIM-1 in non-small cell lung cancer and their effects on prognosis

更新时间：2022-06-24

- Expression of PD-1 and TIM-1 in non-small cell lung cancer and their effects on prognosis
- null Issue 4, Pages: 319(2022)
- 作者机构：
  
  中国人民解放军南部战区总医院呼吸内科,广东,广州,510000
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CHEN Can, ZHENG Lin-xin, MAI Yu-mei, et al. Expression of PD-1 and TIM-1 in non-small cell lung cancer and their effects on prognosis. [J]. null (4):319(2022)
DOI：

CHEN Can, ZHENG Lin-xin, MAI Yu-mei, et al. Expression of PD-1 and TIM-1 in non-small cell lung cancer and their effects on prognosis. [J]. null (4):319(2022) DOI：

摘要

目的探讨非小细胞肺癌（NSCLC）组织中程序性死亡受体-1（PD-1）、T淋巴细胞免疫球蛋白和黏蛋白结构域分子1（TIM-1）的表达及二者对预后的影响。方法选取我院收治的125例NSCLC患者作为研究对象，分别取癌组织及瘤旁组织（距离病灶3～5 cm）以检测PD-1、TIM-1的表达情况。采用Spearman相关系数分析PD-1与TIM-1表达的相关性，并分析二者与临床病理特征的关系。随访24个月，记录患者的生存与死亡情况，采用多因素Cox回归分析影响预后的危险因素，观察不同PD-1、TIM-1表达患者的无瘤生存率与总生存率。结果癌组织中PD-1、TIM-1高表达率高于癌旁组织（P＜0.05），Spearman相关系数分析显示PD-1与TIM-1表达呈正相关（r=0.745，P<0.001）。PD-1、TIM-1高表达组临床分期Ⅲ期、中低分化、淋巴结转移、肿瘤直径≥3 cm的比例高于PD-1、TIM-1低表达组（P＜0.05）。多因素Cox回归分析显示，临床分期Ⅲ期、中低分化、淋巴结转移、肿瘤直径≥3 cm及PD-1、TIM-1高表达是影响预后的危险因素（P＜0.05）。随访期间，125例NSCLC患者中死亡34例（27.20%），生存91例（72.80%），PD-1、TIM-1高表达组的无瘤生存率、总生存率均低于PD-1、TIM-1低表达组（P＜0.001）。结论 NSCLC患者PD-1、TIM-1以高表达为主，二者高表达会降低患者无瘤生存率与总生存率。

Abstract

关键词

非小细胞肺癌程序性死亡受体-1T淋巴细胞免疫球蛋白和黏蛋白结构域分子1预后

Keywords

non-small cell lung cancerprogrammed death receptor-1T cell immunoglobulin and mucin domain-containing molecule-1prognosis

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