Analysis of clinicopathological factors affecting the surgical prognosis of intrahepatic cholangiocarcinoma

LI Xue-jian; ZHANG Cheng-shuo; LI Xiao-hang; BAI Han; ZHANG Jia-lin

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Analysis of clinicopathological factors affecting the surgical prognosis of intrahepatic cholangiocarcinoma

更新时间：2022-06-24

- Analysis of clinicopathological factors affecting the surgical prognosis of intrahepatic cholangiocarcinoma
- null Issue 1, Pages: 65(2022)
- 作者机构：
  
  中国医科大学附属第一医院肝胆外科,辽宁,沈阳,110001
- 作者简介：
- 基金信息：
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LI Xue-jian, ZHANG Cheng-shuo, LI Xiao-hang, et al. Analysis of clinicopathological factors affecting the surgical prognosis of intrahepatic cholangiocarcinoma. [J]. null (1):65(2022)
DOI：

LI Xue-jian, ZHANG Cheng-shuo, LI Xiao-hang, et al. Analysis of clinicopathological factors affecting the surgical prognosis of intrahepatic cholangiocarcinoma. [J]. null (1):65(2022) DOI：

摘要

目的分析影响肝胆管细胞癌（ICC）患者手术预后的临床病理学因素。方法回顾性分析行根治性肝切除术的112例ICC患者的临床资料，统计患者术后1年、3年、5年累积生存率，通过单因素和多因素分析影响ICC患者预后的危险因素，并制作列线图模型。结果 112例患者的中位生存期为27个月，术后1年、3年及5年的累积生存率分别为72.8%、40.7%、34.0%。单因素分析结果显示，癌胚抗原（CEA）、CA19-9、碱性磷酸酶（ALP）、HbsAg、胆管扩张、血管侵犯、局部侵犯、淋巴结转移、卫星结节、肿瘤分化程度、手术切除范围以及肿瘤TNM分期是影响ICC患者肝切除术预后的相关因素；多因素分析结果显示，HbsAg阴性、血管侵犯、卫星结节、肿瘤中低分化以及肿瘤TNM分期为ⅢA/ⅢB期是影响ICC患者预后的独立危险因素。根据多因素分析结果制作的列线图模型能较好地预测ICC患者的术后生存期。结论 HbsAg阴性、血管侵犯、卫星结节、肿瘤中低分化以及肿瘤TNM分期为ⅢA/ⅢB期是影响ICC患者根治性肝切除术后生存期的独立危险因素。

Abstract

关键词

肝切除术肝胆管细胞癌影响因素列线图

Keywords

hepatectomyintrahepatic cholangiocarcinomainfluencing factorsnomogram

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