Effect of PI3K inhibitor TGX-221 on proliferation,cycle and apoptosis of human osteosarcoma cells

JIANG Haoli; GUO Wei; YUAN Shanyou; SONG Lixia

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Effect of PI3K inhibitor TGX-221 on proliferation,cycle and apoptosis of human osteosarcoma cells

更新时间：2022-06-24

- Effect of PI3K inhibitor TGX-221 on proliferation,cycle and apoptosis of human osteosarcoma cells
- null Issue 2, Pages: 93(2020)
- 作者机构：
  
  深圳市第三人民医院骨科,广东,深圳,518000
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JIANG Haoli, GUO Wei, YUAN Shanyou, et al. Effect of PI3K inhibitor TGX-221 on proliferation,cycle and apoptosis of human osteosarcoma cells. [J]. null (2):93(2020)
DOI：

JIANG Haoli, GUO Wei, YUAN Shanyou, et al. Effect of PI3K inhibitor TGX-221 on proliferation,cycle and apoptosis of human osteosarcoma cells. [J]. null (2):93(2020) DOI：

摘要

目的探究PI3K抑制剂TGX221对人骨肉瘤细胞增殖、周期及凋亡的影响。方法培养人骨肉瘤U2OS和MG-63细胞株，分为对照组和实验组，实验组加入10 μmol/L的TGX-221，对照组加入相同剂量的DMSO。处理48 h后，CCK8法检测TGX221对人骨肉瘤细胞活力及增殖的影响；流式细胞术检测TGX-221对人骨肉瘤U2OS和MG63细胞的细胞周期及凋亡的作用。结果CCK8检测结果显示，TGX-221对人骨肉瘤细胞有显著的增殖抑制作用，且具有时间和浓度依赖性；流式细胞术结果显示，TGX-221将U2OS和MG-63细胞周期阻滞在G1期

并诱导人骨肉瘤细胞凋亡

具有显著的抗肿瘤作用。结论 PI3K抑制剂TGX-221能够抑制人骨肉瘤细胞的增殖、阻滞细胞周期并诱导细胞凋亡，可能成为一种潜在的抗肿瘤药物。

Abstract

关键词

TGX221骨肉瘤细胞增殖细胞周期凋亡

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