Application of mild hypothermia cerebral perfusion in treatment of pediatric ventricular septal defect repair under cardiopulmonary bypass

WANG Hong; TANG Huixia; LIU Yang; CHEN Feng

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Application of mild hypothermia cerebral perfusion in treatment of pediatric ventricular septal defect repair under cardiopulmonary bypass

更新时间：2022-06-24

- Application of mild hypothermia cerebral perfusion in treatment of pediatric ventricular septal defect repair under cardiopulmonary bypass
- null Issue 4, Pages: 313(2020)
- 作者机构：
  
  中国医科大学附属盛京医院小儿外科,辽宁,沈阳,110004
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WANG Hong, TANG Huixia, LIU Yang, et al. Application of mild hypothermia cerebral perfusion in treatment of pediatric ventricular septal defect repair under cardiopulmonary bypass. [J]. null (4):313(2020)
DOI：

WANG Hong, TANG Huixia, LIU Yang, et al. Application of mild hypothermia cerebral perfusion in treatment of pediatric ventricular septal defect repair under cardiopulmonary bypass. [J]. null (4):313(2020) DOI：

摘要

目的探讨浅低温脑灌注在体外循环下小儿室间隔缺损修补术中的应用效果。方法回顾性分析2017年2月至2018年7月我院收治的81例行体外循环下小儿室间隔缺损修补术患儿的临床资料，将术中采用浅低温脑灌注治疗的43例患儿设为浅低温组，术中采用中低温下脑灌注治疗的38例患儿设为中低温组。对比2组患儿术中最低鼻咽温度，术中最低直肠温度，术中体外循环时间，术中主动脉阻断时间，术后呼吸支持时间，术后心包和纵隔引流量，麻醉前(T0)、麻醉后10 min(T1)、手术开始后20 min(T2)、手术结束时(T3)血压(BP)及心率(HR)水平变化，术中室颤，术后低血压，术后心律失常及术后短暂性神经功能障碍发生率。结果浅低温组术中最低鼻咽温度、术中最低直肠温度均高于中低温组，差异有统计学意义(P<0.05)，2组术中体外循环时间、术中主动脉阻断时间、术后呼吸支持时间、术后心包和纵隔引流量比较差异无统计学意义(P>0.05);各时刻2组间收缩压(SBP)、舒张压(DBP)、HR组间比较差异无统计学意义(P>0.05)，且2组SBP、DBP和HR水平均先下降后升高，其中T1、T2、T3时刻BP和HR水平均明显低于T0时刻(P<0.05)，T2时刻BP和HR水平均明显低于T1时刻(P<0.05)，T3时刻BP和HR水平均明显高于T2时刻，差异均有统计学意义(P<0.05);浅低温组术后心律失常发生率与中低温组均相近，差异无统计学意义(P>0.05)，浅低温组术中室颤、术后低血压、术后短暂性神经功能障碍发生率均显著低于中低温组，差异有统计学意义(P<0.05)。结论在体外循环下小儿室间隔缺损修补术中，应用浅低温脑灌注治疗可减少术中室颤、术后低血压及术后短暂性神经功能障碍。

Abstract

关键词

脑灌注浅低温中低温小儿室间隔缺损体外循环室间隔缺损修补术

Keywords

cerebral perfusionmild hypothermiamoderate hypothermiapediatric ventricular septal defectcardiopulmonary bypassventricular septal defect repair

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