Importance of trace amine receptor 1 in pathogenesis of Gilles de la Tourette syndrome

Sun Zhiqian; Shi Zhenggang; Feng Peng; Yang Huan; Luo Wenzhen

您当前的位置：

首页 >

文章列表页 >

Importance of trace amine receptor 1 in pathogenesis of Gilles de la Tourette syndrome

更新时间：2022-06-24

- Importance of trace amine receptor 1 in pathogenesis of Gilles de la Tourette syndrome
- Journal of Chongqing Medical University Vol. 47, Issue 1, Pages: 36-38(2022)
- 作者机构：
  
  甘肃中医药大学中医临床学院中医儿科教研室,兰州,730000
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2022，
扫描看全文
Sun Zhiqian, Shi Zhenggang, Feng Peng, et al. Importance of trace amine receptor 1 in pathogenesis of Gilles de la Tourette syndrome. [J]. Journal of Chongqing Medical University 47(1):36-38(2022)
DOI：

Sun Zhiqian, Shi Zhenggang, Feng Peng, et al. Importance of trace amine receptor 1 in pathogenesis of Gilles de la Tourette syndrome. [J]. Journal of Chongqing Medical University 47(1):36-38(2022) DOI：

摘要

痕量胺受体1（trace amine receptor 1，TAAR1）是2001年被发现的G蛋白偶联受体（G protein-coupled receptor，GPCR）家族新成员。相关研究发现，痕量胺（trace amine，TA）有高度敏感性，能够介导TA调控多巴胺（dopamine，DA）能神经元的活动，其本身也是DA能系统的调节剂，与DA能系统功能是否正常联系密切。DA能系统失常也会引起抽动秽语综合征（Gilles de la Tourette syndrome，TS），所以TAAR1为探究TS发病机制提供了新的靶点和方向。

Abstract

Trace amine receptor 1（TAAR1） is a new member of the G protein-coupled receptor（GPCR） family which was discov－ered in 2001. Related studies have found that trace amine（TA） is highly sensitive and can mediate TA regulation of the activity of dopamine（DA） neurons. TAAR1 itself is also a regulator of the DA system，which is closely related to the normal function of the DA system. The disorder of DA energy system can also lead to Gilles de la Tourette syndrome（TS）. Therefore，TAAR1 provides a new target and direction for exploring the pathogenesis of TS.

关键词

多巴胺痕量胺受体1多巴胺能系统抽动秽语综合征

Keywords

dopaminetrace amine receptor 1DA energy systemGilles de la Tourette syndrome

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

THE EFFECT OF CHRONIC AND ACUTE APPLICATION OF LITHIUM SALT ON DOPAMINE CONTENT OF DIFFERENT BRAIN REGIONS OF THE RAT

Neurotransmitters and Gilles de la Tourette syndrome

Related Author

Fang Haili

et al

费汝为

Feng Peng

Related Institution

Department of Physiology

Teaching and Research Section of Pediatrics of Traditional Chinese Medicine, Clinical College of Chinese Medicine, Gansu University of Chinese Medicine

⁰