Objective：To investigate the knowledge comprehension，the adopted measures and mental state regarding 2019 novel coronavirus（2019-nCoV） in patients with old myocardial infarction. Methods：Patients with previous diagnosis of myocardial infarction were follow-up by telephone questionnaire survey based on previously established follow-up system. Results：A total of 610 eligible mobile phone users participated in the survey，46.4% with hypertension. Urban residents was able to acquire more news about 2019-nCoV than rural residents（58.4% vs. 41.6%，P=0.647）；there was no statistical difference in gender（98.7% vs. 99.1%，P=0.647）. Of 40.2% rural residents were not aware of virus transmission routes，which was higher than urban residents of 31.7%（P=0.032）. The protection measure in rural residents was significant lower in urban residents：wearing masks（75.2% vs. 89.9%，P<0.001），avoiding gathering（58.3% vs. 68.3%，P=0.011） and hand hygiene（55.9% vs. 64.3%，P=0.036）. Females without self-protection mea－sures were more when compared with male（14.2% vs. 5.7%，P=0.001） and wearing masks rate in female was less than male（76.1% vs. 86.6%，P=0.002）. All interviewees were in stable state and 94.9% of them were full of confidence about controlling the epidemic. Females be aware of virus transmission route and protective measures in rural areas were weaker than those in urban areas（P<0.05）. Conclusion：The 2019-nCoV susceptible population of old myocardial infarction patients has a high awareness rate of the infection disease and has taken some self-protection measures，however，the knowledge and self-protection are relatively weak among rural res－idents and the female，which should be paid more attention im－prove this situation and residents are confident to conquer the virus.