Objective To study the prescription principles and medication rules of Xing Xuan Medical Records in the treatment of various diseases using the data mining technology. Methods We selected 128 effective medical cases from Xing Xuan Medical Records and extracted the information of prescriptions

with the database established using Office 2010. SPSS statistics 22.0 was used to analyze drug frequency

drug pair frequency

and the nature and category of drugs. Cluster analysis and factor analysis were carried out. Results A total of 128 prescriptions were screened out

involving 234 drugs. The most frequently used single medicines were Radix Glycyrrhizae

Panax ginseng

Poria cocos

prepared Radix Rehmanniae

Angelica sinensis

and Atractylodes macrocephala

most of which entered the liver and spleen meridians. The most frequently used drug pairs were Radix Glycyrrhizae-Panax ginseng

Radix Glycyrrhizae-Angelica sinensis

Radix Glycyrrhizae-Poria cocos

Radix Glycyrrhizae-Atractylodes macrocephala

and Atractylodes macrocephala-Panax ginseng. The most common drugs belonged to deficiency-tonifying drugs

heat-clearing drugs

and diuresis-inducing and dampness-draining drugs. Cluster analysis produced 8 drug combinations; C1 included sour jujube kernel

Saussurea costus

Polygala tenuifolia

ginger

jujube

and Astragalus membranaceus. Factor analysis produced 10 common factors; F1 included Polygala tenuifolia

Saussurea costus

sour jujube kernel

ginger

jujube

and Astragalus membranaceus; F2 included Alisma orientalis

Dioscorea opposita

Comus officinalis

and Cortex Moutan Radicis. Conclusion The prescription of Cheng Wenyou is mainly characterized by tonifying Qi and blood as well as strengthening the spleen

tonifying the kidney

nourishing the stomach

and clearing heat. It focuses on the spleen and stomach

and pays attention to tonifying and nourishing

with concise

precise

and holistic features.